Cloned (Comment) | Organism |
---|---|
overexpression of Flag-tagged p53 or LSD1 in U2OS cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of Flag-tagged p53 or LSD1 in U2OS cells, which express endogenous p53, does not cause a generalized decrease in cellular H3K4me2 levels | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in p53-null mice, LSD1 binding is depleted, H3K4me2 is increased, and H3K9me2 remains unchanged compared to those of the wild type | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | p53 directly interacts with LSD1 to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein, AFP, p53 and LSD1 cooccupy a p53 response element, concomitant with dimethylated histone H3 lysine 4 demethylation and postnatal repression of AFP transcription, overview | ? | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 | Mus musculus | - |
[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | p53 directly interacts with LSD1 to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein, AFP, p53 and LSD1 cooccupy a p53 response element, concomitant with dimethylated histone H3 lysine 4 demethylation and postnatal repression of AFP transcription, overview | Mus musculus | ? | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 | - |
Mus musculus | [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LSD1 | - |
Mus musculus |
lysine-specific demethylase 1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | in p53-null mice, LSD1 binding is depleted, H3K4me2 is increased, and H3K9me2 remains unchanged compared to those of the wild type. Partial hepatectomy of wild-type mouse liver and induces a regenerative response, which leads to a loss of p53, increases H3K4me2, and decreases LSD1 interaction at AFP chromatin, in parallel with reactivation of AFP expression | Mus musculus |
physiological function | LSD1 is targeted to chromatin by p53, likely in a gene-specific manner, and define a molecular mechanism by which p53 mediates transcription repression in vivo during differentiation | Mus musculus |