Cloned (Comment) | Organism |
---|---|
gene SCD, quantitative real-time PCR expression analysis | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | Bos taurus | - |
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? | |
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | Bos taurus | - |
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q9TT94 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cumulus cell | - |
Bos taurus | - |
cumulus-oocyte complex | the level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation | Bos taurus | - |
oocyte | low level expression | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Bos taurus | palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? | |
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ | - |
Bos taurus | oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD | - |
Bos taurus |
SCD1 | - |
Bos taurus |
stearoyl-CoA desaturase | - |
Bos taurus |
stearoyl-CoA desaturase 1 | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
malfunction | chemical SCD1 inhibition in the presence of stearic acid results in a significant induction of apoptosis in cumulus cells of matured cumulus-oocyte complexes. SCD1 inhibition does not affect the levels of palmitic acid and its desaturated form, palmitoleic acid | Bos taurus |
physiological function | cumulus cells can desaturate the potentially toxic stearic acid into oleic acid via stearoyl-CoA desaturase (SCD) activity, cumulus cells protect the oocyte against toxicity by saturated fatty acids. Stearoyl-CoA desaturase 1 activity is related with increased lipid storage in cumulus cells. The level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation | Bos taurus |