Application | Comment | Organism |
---|---|---|
medicine | PHM is a potential target for the development of inhibitors as drugs for the teratment of human disease | Homo sapiens |
medicine | PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease | Rattus norvegicus |
medicine | PHM is a potential target for the development of insecticides | Blattella germanica |
Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(CBZ-hydrazido)glycine | - |
Rattus norvegicus | |
(nicotinamidomethyl)phosphonic acid | - |
Rattus norvegicus | |
(S)-N-CBZ-4-amino-2-hydroxybutyric acid | - |
Rattus norvegicus | |
3-benzoylpropionic acid | - |
Rattus norvegicus | |
6-O-palmitoyl-L-ascorbate | - |
Rattus norvegicus | |
glutathione ethyl ester | - |
Rattus norvegicus | |
N,S-dibenzoyl-L-cysteine | - |
Rattus norvegicus | |
N-(benzoyl)-D-serine | - |
Rattus norvegicus | |
N-(thiobenzoyl)-(D,L)-alanine | - |
Rattus norvegicus | |
N-benzylglycine | - |
Rattus norvegicus | |
N-phenylthiohydantoic acid | - |
Rattus norvegicus | |
O-(phenylcarbamoyl)glycolic acid | - |
Rattus norvegicus | |
O-benzamidoglycolic acid | - |
Rattus norvegicus | |
Pro-Leu-Gly hydroxamic acid | - |
Rattus norvegicus | |
S-(2-phenylthioacetyl)thioglycolic acid | - |
Blattella germanica | |
S-(2-phenylthioacetyl)thioglycolic acid | - |
Homo sapiens | |
S-(2-phenylthioacetyl)thioglycolic acid | - |
Rattus norvegicus | |
S-(3-phenylthiopropionyl)thioglycolic acid | - |
Blattella germanica | |
S-(3-phenylthiopropionyl)thioglycolic acid | - |
Rattus norvegicus | |
S-(4-methylthiobenzoyl)thioglycolic acid | - |
Blattella germanica | |
S-(4-methylthiobenzoyl)thioglycolic acid | - |
Rattus norvegicus | |
S-(4-methylthiobenzoyl)thioglycolic acid ethyl ester | - |
Rattus norvegicus | |
S-(phenylthiocarbamoyl)-3-mercaptopropionic acid | - |
Blattella germanica | |
S-(phenylthiocarbamoyl)-3-mercaptopropionic acid | - |
Rattus norvegicus | |
S-(phenylthiocarbamoyl)thioglycolic acid | - |
Blattella germanica | |
S-(phenylthiocarbamoyl)thioglycolic acid | - |
Rattus norvegicus | |
S-(thiobenzoyl)-(R,S)-thiolactic acid | - |
Rattus norvegicus | |
S-(thiobenzoyl)-4-mercapto-4-cyanopentanoic acid | - |
Rattus norvegicus | |
S-(thiobenzoyl)thioglycolic acid | - |
Blattella germanica | |
S-(thiobenzoyl)thioglycolic acid | - |
Rattus norvegicus | |
S-(thiolauroyl)thioglycolic acid | - |
Rattus norvegicus | |
S-phenylmercaptoacetic acid | - |
Blattella germanica | |
S-phenylmercaptoacetic acid | - |
Rattus norvegicus | |
Salicylhydroxamic acid | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.024 | - |
phenylthioacetylglycine | apparent KM | Rattus norvegicus | |
0.031 | - |
N-dansyl-Tyr-Val-D-Ala | apparent KM | Rattus norvegicus | |
0.036 | - |
2-pyridylmercaptoacetylglycine | apparent KM | Rattus norvegicus | |
0.038 | - |
3-phenylthiopropionylglycine | apparent KM | Rattus norvegicus | |
0.051 | - |
6-phenylhexanoylglycine | apparent KM | Rattus norvegicus | |
0.059 | - |
N-[(benzylmercapto)carbonyl]glycine | apparent KM | Rattus norvegicus | |
0.078 | - |
hippuryl-Gly | apparent KM | Rattus norvegicus | |
0.1 | - |
8-phenyloctanoylglycine | apparent KM | Rattus norvegicus | |
0.11 | - |
4-nitrobenzoyl-Gly-Gly | apparent KM | Rattus norvegicus | |
0.15 | - |
5-phenylpentanoylglycine | apparent KM | Rattus norvegicus | |
0.16 | - |
N-(Phenylacetyl)glycine | apparent KM | Rattus norvegicus | |
0.16 | - |
4-phenylbutyrylglycine | apparent KM | Rattus norvegicus | |
0.19 | - |
phenylmercaptoacetylglycine | apparent KM | Rattus norvegicus | |
0.22 | - |
2-propylmercaptoacetylglycine | apparent KM | Rattus norvegicus | |
0.23 | - |
cinnamoylglycine | apparent KM | Rattus norvegicus | |
0.28 | - |
isocaproylglycine | apparent KM | Rattus norvegicus | |
0.3 | - |
3-indolylacetylglycine | apparent KM | Rattus norvegicus | |
0.3 | - |
tBOC-Gly-Gly | apparent KM | Rattus norvegicus | |
0.31 | - |
L-pyroglutamyl-Gly | apparent KM | Rattus norvegicus | |
0.31 | - |
hippuryl-Gly-Gly | apparent KM | Rattus norvegicus | |
0.36 | - |
phenylhydantoic acid | apparent KM | Rattus norvegicus | |
0.42 | - |
chloroacetyl-Gly-Gly | apparent KM | Rattus norvegicus | |
0.47 | - |
4-nitrohippuric acid | apparent KM | Rattus norvegicus | |
0.52 | - |
4-bromohippuric acid | apparent KM | Rattus norvegicus | |
0.59 | - |
CBZ-glycine | apparent KM | Rattus norvegicus | |
0.62 | - |
4-chlorohippuric acid | apparent KM | Rattus norvegicus | |
0.77 | - |
4-trifluoromethylhippuric acid | apparent KM | Rattus norvegicus | |
0.82 | - |
4-methoxyhippuric acid | apparent KM | Rattus norvegicus | |
0.86 | - |
2-hydroxyhippuric acid | apparent KM | Rattus norvegicus | |
0.9 | - |
N-[(2-phenylcyclopropyl)carbonyl]glycine | apparent KM | Rattus norvegicus | |
0.94 | - |
hydrocinnamoylglycine | apparent KM | Rattus norvegicus | |
1.2 | - |
4-ethylhippuric acid | apparent KM | Rattus norvegicus | |
1.2 | - |
4-propylhippuric acid | apparent KM | Rattus norvegicus | |
1.2 | - |
3-(2-furyl)acryloylglycine | apparent KM | Rattus norvegicus | |
1.3 | - |
hippuric acid | apparent KM | Rattus norvegicus | |
1.4 | - |
2-aminohippuric acid | apparent KM | Rattus norvegicus | |
1.4 | - |
3-methylhippuric acid | apparent KM | Rattus norvegicus | |
1.5 | - |
acetyl-Gly-Gly | apparent KM | Rattus norvegicus | |
1.6 | - |
N-(2-thienylcarbonyl)glycine | apparent KM | Rattus norvegicus | |
1.7 | - |
4-hydroxyhippuric acid | apparent KM | Rattus norvegicus | |
1.8 | - |
4-methylhippuric acid | apparent KM | Rattus norvegicus | |
1.9 | - |
nicotinuric acid | apparent KM | Rattus norvegicus | |
2.2 | - |
3-chlorohippuric acid | apparent KM | Rattus norvegicus | |
2.6 | - |
4-aminohippuric acid | apparent KM | Rattus norvegicus | |
2.7 | - |
N-(2-furoyl)glycine | apparent KM | Rattus norvegicus | |
3.4 | - |
2-iodohippuric acid | apparent KM | Rattus norvegicus | |
3.7 | - |
tBOC-Gly | apparent KM | Rattus norvegicus | |
4.1 | - |
N-(alpha-methylhydrocinnamoyl)glycine | apparent KM | Rattus norvegicus | |
4.3 | - |
2-methylhippuric acid | apparent KM | Rattus norvegicus | |
9.3 | - |
N-acetylglycine | apparent KM | Rattus norvegicus | |
19 | - |
2,6-difluorohippuric acid | apparent KM | Rattus norvegicus | |
35 | - |
CBZ-D-alanine | apparent KM | Rattus norvegicus | |
84 | - |
benzoyl-D-alanine | apparent KM | Rattus norvegicus | |
1400 | - |
acetyl-D-alanine | apparent KM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Blattella germanica | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | P14925 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Blattella germanica |
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
medullary thyroid carcinoma cell | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.01 | - |
N-dansyl-Tyr-Val-Gly | Blattella germanica |
3 | - |
O2 | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,6-difluorohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
2-aminohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
2-hydroxyhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
2-iodohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
2-methylhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
2-propylmercaptoacetylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
2-pyridylmercaptoacetylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
3-(2-furyl)acryloylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
3-chlorohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
3-indolylacetylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
3-methylhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
3-phenylthiopropionylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-aminohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-bromohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-chlorohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-ethylhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-hydroxyhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-methoxyhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-methylhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-nitrobenzoyl-Gly-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-nitrohippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-phenylbutyrylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-propylhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-trifluoromethylhippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
5-phenylpentanoylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
6-phenylhexanoylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
8-phenyloctanoylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
acetyl-D-alanine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
acetyl-Gly-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
benzoyl-D-alanine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
CBZ-D-alanine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
CBZ-glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
chloroacetyl-Gly-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
cinnamoylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
hippuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
hippuryl-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
hippuryl-Gly-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
hydrocinnamoylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
isocaproylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
L-pyroglutamyl-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-(2-furoyl)glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-(2-thienylcarbonyl)glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-(alpha-methylhydrocinnamoyl)glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-(phenylacetyl)glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-acetylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-Dan-Tyr-Val-Gly + ascorbate + O2 | the product is unstable and dismutates to N-Dan-Tyr-Val-NH2 and glyoxylate (EC4.3.2.5) | Blattella germanica | N-Dan-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
N-dansyl-Tyr-Val-D-Ala + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-[(2-phenylcyclopropyl)carbonyl]glycine + ascorbate + O2 | - |
Rattus norvegicus | N-[(2-phenylcyclopropyl)carbonyl]-2-hydroxyglycine + dehydroascorbate + H2O | - |
r | |
N-[(benzylmercapto)carbonyl]glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
N-[(phenylcyclopropyl)carbonyl]glycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
nicotinuric acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
phenylhydantoic acid + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
phenylmercaptoacetylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
phenylthioacetylglycine + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
tBOC-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? | |
tBOC-Gly-Gly + ascorbate + O2 | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAM | - |
Blattella germanica |
PAM | - |
Rattus norvegicus |
peptidylglycine alpha-hydroxylating monooxygenase | - |
Homo sapiens |
peptidylglycine alpha-hydroxylating monooxygenase | - |
Blattella germanica |
peptidylglycine alpha-hydroxylating monooxygenase | - |
Rattus norvegicus |
PHM | - |
Homo sapiens |
PHM | - |
Blattella germanica |
PHM | - |
Rattus norvegicus |
type A PAM | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Blattella germanica |
37 | - |
activity assay | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Blattella germanica |
6 | - |
activity assay | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00054 | - |
S-(thiolauroyl)thioglycolic acid | Ki,s | Rattus norvegicus | |
0.0026 | - |
S-(phenylthiocarbamoyl)-3-mercaptopropionic acid | Ki,s | Rattus norvegicus | |
0.0035 | - |
S-(4-methylthiobenzoyl)thioglycolic acid | Ki,s | Rattus norvegicus | |
0.0057 | - |
S-(thiobenzoyl)-4-mercapto-4-cyanopentanoic acid | Ki,s | Rattus norvegicus | |
0.0072 | - |
N-(thiobenzoyl)-(D,L)-alanine | Ki,s | Rattus norvegicus | |
0.0079 | - |
S-(2-phenylthioacetyl)thioglycolic acid | Ki,s | Rattus norvegicus | |
0.0086 | - |
S-(phenylthiocarbamoyl)thioglycolic acid | Ki,s | Rattus norvegicus | |
0.0094 | - |
S-(3-phenylthiopropionyl)thioglycolic acid | Ki,s | Rattus norvegicus | |
0.035 | - |
6-O-palmitoyl-L-ascorbate | Ki,s | Rattus norvegicus | |
0.039 | - |
S-(thiobenzoyl)thioglycolic acid | Ki,s | Rattus norvegicus | |
0.054 | - |
O-(phenylcarbamoyl)glycolic acid | Ki,s | Rattus norvegicus | |
0.058 | - |
S-(thiobenzoyl)-(R,S)-thiolactic acid | Ki,s | Rattus norvegicus | |
0.066 | - |
glutathione ethyl ester | Ki,s | Rattus norvegicus | |
0.069 | - |
N,S-dibenzoyl-L-cysteine | Ki,s | Rattus norvegicus | |
0.11 | - |
N-phenylthiohydantoic acid | Ki,s | Rattus norvegicus | |
0.11 | - |
S-(4-methylthiobenzoyl)thioglycolic acid ethyl ester | Ki,s | Rattus norvegicus | |
0.3 | - |
Salicylhydroxamic acid | Ki,s | Rattus norvegicus | |
0.38 | - |
S-phenylmercaptoacetic acid | Ki,s | Rattus norvegicus | |
1 | - |
O-benzamidoglycolic acid | Ki,s | Rattus norvegicus | |
1 | - |
Pro-Leu-Gly hydroxamic acid | Ki,s | Rattus norvegicus | |
1.4 | - |
(S)-N-CBZ-4-amino-2-hydroxybutyric acid | Ki,s | Rattus norvegicus | |
1.5 | - |
N-(benzoyl)-D-serine | Ki,s | Rattus norvegicus | |
2.9 | - |
3-benzoylpropionic acid | Ki,s | Rattus norvegicus | |
7.9 | - |
(CBZ-hydrazido)glycine | Ki,s | Rattus norvegicus | |
18 | - |
N-benzylglycine | Ki,s | Rattus norvegicus | |
75 | - |
(nicotinamidomethyl)phosphonic acid | Ki,s, larger than 75 | Rattus norvegicus |