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Literature summary for 1.14.16.4 extracted from
- Aromatic amino acid hydroxylases (1987), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 18, 217-282.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iron chelators | - |
Bos taurus | |
| iron chelators | - |
Canis lupus familiaris | |
| iron chelators | - |
Oryctolagus cuniculus | |
| iron chelators | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
| soluble | - |
Bos taurus | - |
- |
| soluble | - |
Oryctolagus cuniculus | - |
- |
| soluble | - |
Canis lupus familiaris | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | enzyme from pineal gland, stimulation | Rattus norvegicus |  |
| Fe2+ | enzyme from pineal gland, stimulation | Bos taurus | |
| Fe2+ | enzyme from pineal gland, stimulation | Oryctolagus cuniculus | |
| Fe2+ | enzyme from pineal gland, stimulation | Canis lupus familiaris | |
| Fe2+ | some brain enzymes are stimulated others not | Rattus norvegicus | |
| Fe2+ | some brain enzymes are stimulated others not | Bos taurus | |
| Fe2+ | some brain enzymes are stimulated others not | Oryctolagus cuniculus | |
| Fe2+ | some brain enzymes are stimulated others not | Canis lupus familiaris | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57500 | - |
2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE | Oryctolagus cuniculus |
| 60000 | - |
2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE | Oryctolagus cuniculus |
| 220000 | 240000 | enzyme from hindbrain | Oryctolagus cuniculus |
| 288000 | - |
- |
Rattus norvegicus |
| 300000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydropteridine + O2 | Rattus norvegicus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | Bos taurus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | Oryctolagus cuniculus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | Canis lupus familiaris | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Canis lupus familiaris | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
| tryptophan hydroxylase form I and II, pH 4.8, ammonium sulfate, gel filtration, DEAE-Sepharose, 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine-agarose | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| brain | - |
Oryctolagus cuniculus | - |
| brain | activity in hypothalamus and midbrain-medulla regions, no activity in cerebellum or cortex | Canis lupus familiaris | - |
| intestinal mucosa | - |
Rattus norvegicus | - |
| intestinal mucosa | - |
Bos taurus | - |
| intestinal mucosa | - |
Oryctolagus cuniculus | - |
| intestinal mucosa | - |
Canis lupus familiaris | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Canis lupus familiaris | - |
| pineal gland | - |
Rattus norvegicus | - |
| pineal gland | - |
Bos taurus | - |
| pineal gland | - |
Oryctolagus cuniculus | - |
| pineal gland | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydropteridine + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | - |
Bos taurus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | - |
Oryctolagus cuniculus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | - |
Canis lupus familiaris | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Bos taurus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Oryctolagus cuniculus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Canis lupus familiaris | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Rattus norvegicus |
| tetramer | 2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE | Oryctolagus cuniculus |
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