Literature summary for 1.14.15.37 extracted from

He, J.; Mueller, M.; Hertweck, C.
Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase (2004), J. Am. Chem. Soc., 126, 16742-16743 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Streptomyces lividans	Streptomyces thioluteus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces thioluteus	Q70KH6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
luteothin + 2 O2 + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+	luteothin i.e. deoxyaureothin	Streptomyces thioluteus	aureothin + 3 H2O + 4 oxidized ferredoxin [iron-sulfur] cluster	-	?

General Information

General Information	Comment	Organism
physiological function	knockout of AurH in the aureothin biosynthesis gene cluster leads to accumulation of luteothin. AurH catalyzes the formation of the homochiral furan ring of aureothin, which constitutes the last step in the biosynthetic pathway	Streptomyces thioluteus

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Release 2023.1 (January 2023)