Literature summary for 1.14.15.36 extracted from

Jackson, C.J.; Lamb, D.C.; Marczylo, T.H.; Parker, J.E.; Manning, N.L.; Kelly, D.E.; Kelly, S.L.
Conservation and cloning of CYP51 a sterol 14 alpha-demethylase from Mycobacterium smegmatis (2003), Biochem. Biophys. Res. Commun., 301, 558-563 .

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Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
lanosterol + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2	-	Mycolicibacterium smegmatis	? + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O	-	?

Subunits

Subunits	Comment	Organism
?	x * 51600, SDS-PAGE	Mycolicibacterium smegmatis

Synonyms

Synonyms	Comment	Organism
CYP51	-	Mycolicibacterium smegmatis

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P450	the oxidized absolute spectrum of the purified CYP51, in the absence of substrate, shows a Soret band at 417 nm and alpha-, beta-, and delta-bands at 569, 535, and 369 nm	Mycolicibacterium smegmatis

General Information

General Information	Comment	Organism
physiological function	the protein binds azole antifungals with high affinity and the rank order based on affinity matches the ranked order for microbiological sensitivity of the organism	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)