Literature summary for 1.14.14.18 extracted from

Tseng, C.K.; Lin, C.K.; Wu, Y.H.; Chen, Y.H.; Chen, W.C.; Young, K.C.; Lee, J.C.
Human heme oxygenase 1 is a potential host cell factor against dengue virus replication (2016), Sci. Rep., 6, 32176 .

Search for more literature for 1.14.14.18

Application

Application	Comment	Organism
medicine	induction or exogenous overexpression of heme oxygenase HO-1 effectively inhibits Dengue virus DENV replication in DENV-infected Huh-7 cells. This antiviral is attenuated by inhibitor tin protoporphyrin. Biliverdin but not carbon monoxide and ferrous ions, mediates the HO-1-induced anti-DENV effect by non-competitively inhibiting DENV protease. HO-1 induction or its exogenous overexpression, rescues DENV-suppressed antiviral interferon response. HO-1 induction by cobalt protoporphyrin and andrographolide leads to a significant delay in the onset of disease and mortality, and virus load in the infected mice's brains	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96DI8	-	-

Synonyms

Synonyms	Comment	Organism
Hmox1	-	Homo sapiens
Ho1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	HO-1 expression is induced by cobalt protoporphyrin and andrographolide	up

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)