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Literature summary for 1.14.14.18 extracted from

  • Heinzl, G.A.; Huang, W.; Yu, W.; Giardina, B.J.; Zhou, Y.; MacKerell, A.D.; Wilks, A.; Xue, F.
    Iminoguanidines as allosteric inhibitors of the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa (2016), J. Med. Chem., 59, 6929-6942 .
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking of inhibitor (E)-2-(4-isopropylbenzylidene)hydrazinecarboximidamide to HemO on the back site and the heme site Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-(4-isopropylbenzylidene)hydrazinecarboximidamide compound shows a binding affinity of 5.7 microM and an MIC50 of 52.3 microg/ml against Pseudomonas aeruginosa PAO1 and increased activity against clinical isolates of Pseudomonas aeruginosa Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa O69002
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