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Literature summary for 1.14.14.121 extracted from
- Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng (2012), Plant Cell Physiol., 53, 1535-1545.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Saccharomyces cerevisiae WAT21 cells | Panax ginseng |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55300 | - |
x * 55300, calculated from amino acid sequence | Panax ginseng |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protopanaxadiol + [reduced NADPH-hemoprotein reductase] + O2 | Panax ginseng | - |
protopanaxatriol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Panax ginseng | I7C6E8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| flower bud | - |
Panax ginseng | - |
| leaf | - |
Panax ginseng | - |
| petiole | - |
Panax ginseng | - |
| rhizome | highest expression | Panax ginseng | - |
| root | - |
Panax ginseng | - |
| sympodium | - |
Panax ginseng | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protopanaxadiol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Panax ginseng | protopanaxatriol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 55300, calculated from amino acid sequence | Panax ginseng |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP716A53v2 | - |
Panax ginseng |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Panax ginseng | the enzyme is not affected by methyl jasmonate treatment | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | protopanaxadiol 6-hydroxylase produces protopanaxatriol from protopanaxadiol, which is an important step in the formation of dammarane-type triterpene aglycones in ginseng saponin biosynthesis | Panax ginseng |
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Release 2023.1 (January 2023)
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