Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chlorpromazine | competitively inhibits oxygenation of methimazole by FMO | Bos taurus | |
imipramine | competitively inhibits oxygenation of methimazole by FMO | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
Methimazole | pH 8.0, 37°C | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Bos taurus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00238 | - |
liver microsomes, substrate methimazole | Bos taurus |
0.00373 | - |
liver microsomes, substrate imipramine | Bos taurus |
0.00375 | - |
liver microsomes, substrate chlorpromazine | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chlorpromazine + NADPH + H+ + O2 | - |
Bos taurus | chlorpromazine oxide + NADP+ + H2O | - |
? | |
imipramine + NADPH + H+ + O2 | - |
Bos taurus | imipramine oxide + NADP+ + H2O | - |
? | |
methimazole + NADPH + H+ + O2 | - |
Bos taurus | methimazole S-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMO | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Bos taurus |