BRENDA - Enzyme Database
show all sequences of 1.14.13.70

Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14alpha-demethylase

Park, J.W.; Byrd, A.; Lee, C.M.; Morgan, E.T.; Biochem. J. 474, 3241-3252 (2017)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
nitric oxide
in Huh7 human hepatoma cells, treatment with nitric oxide donors causes rapid post-translational down-regulation of the enzyme
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
Q16850
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Huh-7 cell
-
Homo sapiens
-
Synonyms
Synonyms
Commentary
Organism
CYP51A1
-
Homo sapiens
lanosterol 14alpha-demethylase
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
nitric oxide
in Huh7 human hepatoma cells, treatment with nitric oxide donors causes rapid post-translational down-regulation of the enzyme
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Huh-7 cell
-
Homo sapiens
-
General Information
General Information
Commentary
Organism
metabolism
the enzyme is required for synthesis of cholesterol and other sterols in mammals
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the enzyme is required for synthesis of cholesterol and other sterols in mammals
Homo sapiens
Other publictions for EC 1.14.13.70
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744274
Park
Nitric oxide stimulates cellu ...
Homo sapiens
Biochem. J.
474
3241-3252
2017
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
744843
Emami
An overview of azoles targeti ...
Leishmania major, Leishmania mexicana, Leishmania infantum
Eur. J. Med. Chem.
135
241-259
2017
-
6
-
-
-
-
39
-
-
-
-
-
-
3
-
-
-
-
-
6
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
4
-
6
-
-
-
-
-
4
39
-
-
-
-
-
-
-
-
-
-
-
6
-
-
6
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
744860
Borcea
-
Synthesis and molecular docki ...
Candida albicans SC5314
Farmacia
65
683-689
2017
-
-
-
-
-
-
10
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745117
Stana
Design, synthesis and antifun ...
Candida albicans SC5314
Int. J. Mol. Sci.
18
E177
2017
-
2
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745378
Hargrove
Structural analyses of Candid ...
Candida albicans
J. Biol. Chem.
292
6728-6743
2017
-
-
1
1
-
-
8
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
8
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
745682
Alvarez-Rueda
The amino acid substitution N ...
Candida albicans
Med. Mycol.
54
764-775
2016
-
-
1
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746216
Tyndall
Structural and functional elu ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YJM789
PLoS ONE
11
e0167485
2016
-
-
1
1
2
-
7
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
7
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746454
Warrilow
Azole antifungal sensitivity ...
Malassezia globosa, Malassezia globosa CBS 7966
Sci. Rep.
6
27690
2016
-
-
1
-
-
-
4
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
5
-
1
1
-
-
3
1
-
-
-
-
-
4
-
-
1
-
-
-
-
4
4
-
3
-
-
-
-
-
-
-
1
-
-
-
-
5
-
1
-
-
3
1
-
-
-
-
-
-
-
3
3
744385
Morrison
Identification, modeling and ...
Danio rerio
Biochim. Biophys. Acta
1840
1825-1836
2014
-
-
1
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745522
Friggeri
Structural basis for rational ...
Trypanosoma cruzi, Trypanosoma cruzi CL Brener
J. Med. Chem.
57
6704-6717
2014
-
2
1
1
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-