BRENDA - Enzyme Database
show all sequences of 1.14.13.247

Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine

Kumar, R.; Zhao, S.; Vetting, M.; Wood, B.; Sakai, A.; Cho, K.; Solbiati, J.; Almo, S.; Sweedler, J.; Jacobson, M.; Gerlt, J.; Cronan, J.; mBio 5, e00933-13 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-proline betaine + NADH + H+ + O2
Paracoccus denitrificans
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADH + H+ + O2
Luteovulum sphaeroides
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADH + H+ + O2
Luteovulum sphaeroides 2.4.1
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADH + H+ + O2
Paracoccus denitrificans Pd1222
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Paracoccus denitrificans
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Luteovulum sphaeroides
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Luteovulum sphaeroides 2.4.1
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Paracoccus denitrificans Pd1222
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Luteovulum sphaeroides
-
-
-
Luteovulum sphaeroides 2.4.1
-
-
-
Paracoccus denitrificans
-
-
-
Paracoccus denitrificans Pd1222
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides 2.4.1
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans Pd1222
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides 2.4.1
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans Pd1222
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
HpbB1-HpbC1
-
Paracoccus denitrificans
HpbB1-HpbC1
-
Luteovulum sphaeroides
HpbB2-HpbC2
-
Paracoccus denitrificans
HpbB2-HpbC2
-
Luteovulum sphaeroides
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Paracoccus denitrificans
NADH
-
Luteovulum sphaeroides
NADPH
-
Paracoccus denitrificans
NADPH
-
Luteovulum sphaeroides
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Paracoccus denitrificans
NADH
-
Luteovulum sphaeroides
NADPH
-
Paracoccus denitrificans
NADPH
-
Luteovulum sphaeroides
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-proline betaine + NADH + H+ + O2
Paracoccus denitrificans
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADH + H+ + O2
Luteovulum sphaeroides
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADH + H+ + O2
Luteovulum sphaeroides 2.4.1
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADH + H+ + O2
Paracoccus denitrificans Pd1222
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Paracoccus denitrificans
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Luteovulum sphaeroides
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Luteovulum sphaeroides 2.4.1
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
L-proline betaine + NADPH + H+ + O2
Paracoccus denitrificans Pd1222
L-proline betaine is also called N,N-dimethylproline or stachydrine
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides 2.4.1
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans Pd1222
N-methyl-L-proline + formaldehyde + NAD+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Luteovulum sphaeroides 2.4.1
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
L-proline betaine + NADPH + H+ + O2
L-proline betaine is also called N,N-dimethylproline or stachydrine
757552
Paracoccus denitrificans Pd1222
N-methyl-L-proline + formaldehyde + NADP+ + H2O
-
-
-
?
Other publictions for EC 1.14.13.247
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
757552
Kumar
Prediction and biochemical de ...
Paracoccus denitrificans, Luteovulum sphaeroides, Luteovulum sphaeroides 2.4.1, Paracoccus denitrificans Pd1222
mBio
5
e00933-13
2014
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757058
Daughtry
Quaternary ammonium oxidative ...
Sinorhizobium meliloti
J. Am. Chem. Soc.
134
2823-2834
2012
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