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Literature summary for 1.14.13.225 extracted from
- MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking (2021), EMBO Rep., 22, e52006 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O94851 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| NCI-H1299 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MICAL2PV | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | splicing isoform MICAL2PV is a tunneling nanotubes (TNT) regulator that suppresses TNT formation and modulates mitochondrial distribution. MICAL2PV interacts with mitochondrial Rho GTPase Miro2 and regulates subcellular mitochondrial trafficking. Downregulation of MICAL2PV enhances survival of cells treated with chemotherapeutical drugs. The monooxygenase domain of MICAL2PV is required for its activity to inhibit TNT formation by depolymerizing F-actin | Homo sapiens |
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