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Literature summary for 1.14.11.69 extracted from

  • Pfister, S.X.; Ahrabi, S.; Zalmas, L.P.; Sarkar, S.; Aymard, F.; Bachrati, C.Z.; Helleday, T.; Legube, G.; La Thangue, N.B.; Porter, A.C.; Humphrey, T.C.
    SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability (2014), Cell Rep., 7, 2006-2018 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens O75164
-
-

General Information

General Information Comment Organism
physiological function reducing H3K36me3 levels by overexpressing KDM4A reduces homologous recombination repair events. Tumor suppressor SETD2 is also required for homologous recombination repair events Homo sapiens