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Literature summary for 1.14.11.68 extracted from
- H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERalpha ligand dependency (2011), EMBO J., 30, 3947-3961 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | H3K27 methylation imposes ligand-dependent regulation of the estrogen receptor alpha-dependent apoptotic response via Bcl-2 in breast cancer cells. The activation of BCL2 transcription is dependent on the simultaneous inactivation of the H3K27 methyltransferase, EZH2, and the demethylation of H3K27 at a poised enhancer by the estrogen receptor alpha-dependent recruitment of JMJD3 in hormone-dependent breast cancer cells. This pathway is modified in cells resistant to anti-estrogen, which constitutively express BCL2 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
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Release 2023.1 (January 2023)
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