Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UPP1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
HUVEC cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PHF8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PHF8 interacts with U1 spliceosomal proteins, such as SRPK1 and snRNP70. The histocompatibility antigen HLA-G is a target of PHF8. The inclusion of HLA-G intron 4, with concomitant RNA Polymerase II accumulation at this intron is controlled by PHF8 and H3K9. Soluble HLA-G is generated after PHF8 knockdown, which leads to reduced T-cell proliferation | Homo sapiens |