Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q63679 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C3H10T1/2 cell | - |
Rattus norvegicus | - |
smooth muscle cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
JMJD1A | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | Jmjd1a binds myocardin-related transcription factor-A, and the jumonjiC domain of Jmjd1a is sufficient to mediate this interaction. Overexpression of Jmjd1a in multipotential 10T1/2 cells decreases global levels of dimethyl H3K9, stimulates alpha-actin and SM22 promoters, and synergistically enhances MRTF-A- and myocardin-dependent transactivation. TGF-beta-mediated upregulation of smooth muscle cell differentiation marker gene expression in 10T1/2 cells is associated with decreased H3K9 dimethylation at the CArG-containing regions of the smooth muscle cell differentiation marker gene promoters. Knockdown of Jmjd1a in 10T1/2 cells and primary rat aortic smooth muscle cells attenuates TGF-beta-induced upregulation of endogenous smooth muscle myosin heavy chain expression concomitant with increased H3K9 dimethylation at the differentiation marker gene promoters | Rattus norvegicus |