Application | Comment | Organism |
---|---|---|
medicine | FTO is up-regulated in human breast cancer. High level of FTO is significantly associated with lower survival rates in patients with breast cancer. FTO promotes breast cancer cell proliferation, colony formation and metastasis in vitro and in vivo. BNIP3, a pro-apoptosis gene, is a downstream target of FTO-mediated m6A modification. BNIP3 acts as a tumor suppressor and is negatively correlated with FTO expression in clinical breast cancer patients. BNIP3 dramatically alleviates FTO-dependent tumor growth retardation and metastasis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9C0B1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |