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Literature summary for 1.14.11.2 extracted from

  • Xiong, G.; Deng, L.; Zhu, J.; Rychahou, P.G.; Xu, R.
    Prolyl-4-hydroxylase alpha subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition (2014), BMC Cancer, 14, 1-1 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Application

Application Comment Organism
diagnostics the prolyl-4-hydroxylase alpha subunit 2 is a biomarker for breast cancer progression. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status Homo sapiens
medicine the prolyl-4-hydroxylase alpha subunit 2 is a potential therapeutic target for the disorders associated with increased collagen deposition and a biomarker for breast cancer progression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene P4HA2, enzyme expression analysis, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information recombinant expression of sh-P4HA2-1 and sh-P4HA2-2 in breast cancer cell lines HMT-3522 T4-2, MDA-MB-231, ZR-75-1, and MDA-MB-157 for gene silencing, phenotypes, detailed overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,4-dihydrophenanthrolin-4-one-3-carboxylic acid 1,4,DPCA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Homo sapiens 31012
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15460
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
breast cancer cell P4HA2 mRNA levels are significantly upregulated in breast cancer compared to normal mammary tissue Homo sapiens
-
HMT-3522 T4-2 cell
-
 Homo sapiens
-
mammary gland
-
 Homo sapiens
-
MDA-MB-157 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
ZR-75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
collagen prolyl-4-hydroxylase alpha subunit 2
-
 Homo sapiens
P4ha2
-
 Homo sapiens
prolyl-4-hydroxylase alpha subunit 2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction silencing P4HA2 expression or treatment with a P4HA inhibitor significantly inhibits cell proliferation and suppresses aggressive phenotypes of breast cancer cells in 3D culture, accompanied by reduced deposition of collagen I and IV. Knockdown of P4HA2 inhibits mammary tumor growth and metastasis to lungs in xenograft models. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status. Kaplan-Meier survival analysis, overview Homo sapiens
physiological function collagen prolyl-4-hydroxylase alpha subunit 2 (P4HA2) hydroxylates proline residues in -X-Pro-Gly- sequences. Expression and function of P4HA2 in breast cancer progression, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression Homo sapiens