Application | Comment | Organism |
---|---|---|
analysis | assay method for screening the inhibitors of prolyl 4-hydroxylase to treat fibrosis. The assay uses rat hepatic stellate HSC-6 cells and cobalt chloride as a substitue for a hypoxic condition, the procedure takes three days after treatment with agents | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
HOE077 | decrease in enzyme activity by 15% | Rattus norvegicus | |
rosiglitazone | decrease in enzyme activity by 32.3% | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HSC-T6 cell | treatment with ascorbate in a hypoxic condition for 24 h results in the maximal increase of hydroxyproline by 1.8-fold. The presence of cobalt chloride can substitute for hypoxic condition | Rattus norvegicus | - |