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Literature summary for 1.13.11.52 extracted from

  • Eleftheriadis, T.; Pissas, G.; Sounidaki, M.; Tsogka, K.; Antoniadis, N.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I.
    Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferaseI activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells (2016), Int. J. Mol. Med., 38, 1605-1613 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD4+ cell
-
 Homo sapiens
-
additional information indoleamine 2,3-dioxygenase (IDO) is expressed in antigen-presenting cells Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells. The enzyme has an immunoregulatory role in various models of autoimmunity and allotrans­plantation. IDO increases fatty acid oxidation in mixed lymphocyte reactions and CPT1 enzy­matic activity in mixed lymphocyte reaction-derived CD4+ T-cells. IDO decreases ACC2 expression, whereas it increases the level of phosphorylated ACC2 in mixed lymphocyte reaction-derived CD4+ T-cells. IDO increases L-tryptophan degradation in mixed lymphocyte reactions enhances eIF2alpha phosphorylation and CYP1A1 expression in mixed lymphocyte reaction-derived CD4+ T-cells, but does not affect p70S6K phosphorylation in mixed lymphocyte reaction-derived CD4+ T-cells Homo sapiens