Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-epicatechin | - |
Homo sapiens | |
11alpha,13-dihydrohelenalin acetate | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
2,3,4',5-tetrahydroxystilbene-2-O-D-glucoside | polymorphonuclear leukocyte | Rattus norvegicus | |
4-methylesculetin | polymorphonuclear leukocyte | Rattus norvegicus | |
beta-hydroxyacteoside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
capsaicin | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
daphnetin | polymorphonuclear leukocyte | Rattus norvegicus | |
esculetin | polymorphonuclear leukocyte | Rattus norvegicus | |
falcarindiol | - |
Sus scrofa | |
forsythiaside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
forsythiaside | polymorphonuclear leukocyte | Rattus norvegicus | |
fraxetin | polymorphonuclear leukocyte | Rattus norvegicus | |
gingerdione | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
helenalin | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
isoriccardin C | - |
Sus scrofa | |
leucocyanidol | polymorphonuclear leukocyte | Rattus norvegicus | |
marchantin A | - |
Sus scrofa | |
marchantin B | - |
Sus scrofa | |
marchantin D | - |
Sus scrofa | |
marchantin E | - |
Sus scrofa | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases | Bos taurus | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Cavia porcellus | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Glycine max | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Helianthus tuberosus | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Mus musculus | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Rattus norvegicus | |
additional information | plant extracts with inhibitory activity on arachidonate 5-lipoxygenase, inhibition of the 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. | Sus scrofa | |
myrtol | enzyme from RBL-1 cell | Rattus norvegicus | |
oroxindin | polymorphonuclear leukocyte | Rattus norvegicus | |
paleatin B | - |
Sus scrofa | |
panaxynol | - |
Sus scrofa | |
perrottetin D | - |
Sus scrofa | |
piceid | polymorphonuclear leukocyte | Rattus norvegicus | |
quercetagetin-7-O-beta-D-glucoside | polymorphonuclear leukocyte | Rattus norvegicus | |
radulanin H | - |
Sus scrofa | |
resveratrol | polymorphonuclear leukocyte | Rattus norvegicus | |
shogaol | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
sideritoflavone | polymorphonuclear leukocyte | Rattus norvegicus | |
suspensaside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
suspensaside | polymorphonuclear leukocyte | Rattus norvegicus | |
tambuletin | polymorphonuclear leukocyte | Rattus norvegicus | |
verbascoside | enzyme from polymorphonuclear leukocyte | Homo sapiens | |
verbascoside | polymorphonuclear leukocyte | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cavia porcellus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Mus musculus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Homo sapiens | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Rattus norvegicus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Sus scrofa | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Bos taurus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Glycine max | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? | |
additional information | Helianthus tuberosus | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cavia porcellus | - |
- |
- |
Glycine max | - |
- |
- |
Helianthus tuberosus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Homo sapiens | - |
granulocyte | - |
Homo sapiens | - |
leukocyte | - |
Sus scrofa | - |
macrophage | - |
Homo sapiens | - |
mast cell | - |
Rattus norvegicus | - |
neutrophil | - |
Homo sapiens | - |
polymorphonuclear leukocyte | - |
Homo sapiens | - |
polymorphonuclear leukocyte | - |
Rattus norvegicus | - |
polymorphonuclear leukocyte | - |
Bos taurus | - |
polymorphonuclear leukocyte | peritoneal | Cavia porcellus | - |
polymorphonuclear leukocyte | peritoneal | Mus musculus | - |
RBL-1 cell | basophilic leukemia cell | Rattus norvegicus | - |
seedling | - |
Helianthus tuberosus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Cavia porcellus | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Mus musculus | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Homo sapiens | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Rattus norvegicus | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Sus scrofa | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Bos taurus | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Glycine max | ? | - |
? | |
additional information | key enzyme in leukotriene biosynthesis, catalyzes the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions | Helianthus tuberosus | ? | - |
? |