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Literature summary for 1.13.11.33 extracted from
- Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors (2019), Naunyn Schmiedebergs Arch. Pharmacol., 392, 1491-1502 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine | - |
Homo sapiens | |
| adamantyl caffeate | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.074 mM | Homo sapiens |  |
| bornyl vanillate | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.401 mM | Homo sapiens | |
| fenchyl caffeate | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.089 mM | Homo sapiens | |
| additional information | stylosin and some similar synthetic monoterpenoids show inhibitory effects on 15-LOX. A strong positive correlation is observed between 15-LOX inhibition potential and cytotoxicity of the compounds with apoptosis being the predominant mechanism of induced cell death | Homo sapiens | |
| stylosin | IC50 value of cytotoxicity against PC-3 cells, 24 h, is 0.101 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P16050 | cf. EC 1.13.11.12, EC 1.13.11.31 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
| PC-3 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| linoleate + O2 | - |
Homo sapiens | (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 15-LOX-1 | - |
Homo sapiens |
| Alox15 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
pH 7.0, 25°C | Homo sapiens | fenchyl caffeate | |
| 0.0171 | - |
pH 7.0, 25°C | Homo sapiens | 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine | |
| 0.0261 | - |
pH 7.0, 25°C | Homo sapiens | adamantyl caffeate | |
| 0.0668 | - |
pH 7.0, 25°C | Homo sapiens | stylosin | |
| 0.399 | - |
pH 7.0, 25°C | Homo sapiens | bornyl vanillate | |
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