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Literature summary for 1.13.11.33 extracted from

  • Bhattacharya, S.; Mathew, G.; Jayne, D.G.; Pelengaris, S.; Khan, M.
    15-lipoxygenase-1 in colorectal cancer: a review (2009), Tumour Biol., 30, 185-199.
    View publication on PubMed
Search for more literature for 1.13.11.33

Application

Application Comment Organism
medicine 15-LOX-1 and its metabolites (13-S-hydroxyoctadecadienoic acid and 15-S-hydroxyeicosatetraenoic acid) have anti-carcinogenic effects in colorectal cancer. 15-LOX-1 is possibly of prognostic value in stage IV colon cancer survival Homo sapiens
medicine has anti-carcinogenic effects in colorectal cancer Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
HCT-116 and LoVo cells transfected with 15-LOX-1 vector Homo sapiens
transgenic mice models overexpressing 15-LOX in endothelial cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
anthraquinone
-
 Homo sapiens
baicalein
-
 Homo sapiens
caffeic acid specific inhibitor of 15-LOX-1 Homo sapiens
esculetin
-
 Homo sapiens
GATA-6 inhibits non-steroidal anti-inflammatory drugs-induced transcription of 15-LOX-1 in colorectal cancer cells Homo sapiens
additional information 15-LOX-1 can be inactivated by epigenetic silencing, hypermethylation of the CpG islands of the 15-LOX-1 promoter results in its reduced transcription in cancers, e.g. lymphomas, lung, prostate and cervix cancers. Brominated phenol esters are potent 15-LOX-1 inhibitors Homo sapiens
nor-dihydro-guaiaretic acid
-
 Homo sapiens
quercetin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm 15-LOX-1, in epithelial cells within the tumour and surrounding normal tissue Homo sapiens 5737
-
additional information 15-LOX-1, in the stroma of fibroblasts Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
colon 15-LOX-1 but not 15-LOX-2 Homo sapiens
-
cornea 15-LOX-2 Homo sapiens
-
eosinophil 15-LOX-1 Homo sapiens
-
epithelium of the tracheobronchial tree, 15-LOX-1 Homo sapiens
-
fibroblast 15-LOX-1 Homo sapiens
-
IEC-6 cell
-
 Rattus norvegicus
-
lung 15-LOX-2 Homo sapiens
-
additional information 15-LOX-1 and -2 are preferentially expressed in normal tissue, present in HTB-38 cells Homo sapiens
-
additional information is preferentially expressed in normal tissue Mus musculus
-
prostate 15-LOX-2 Homo sapiens
-
reticulocyte 15-LOX-1 Homo sapiens
-
skin 15-LOX-1 and 15-LOX-2 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 both 15-LOX-1 and -2 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?
linoleic acid + O2 both 15-LOX-1, 15-LOX-2 reacts with linoleic acid poorly Homo sapiens 13-S-hydroxyoctadecadienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
12/15-LOX
-
 Homo sapiens
12/15-LOX
-
 Mus musculus
15-lipoxygenase-1
-
 Homo sapiens
15-LOX-1
-
 Homo sapiens
15-LOX-1
-
 Rattus norvegicus
15-LOX-2
-
 Homo sapiens
Alox15
-
 Mus musculus
reticulocyte-type of 15-LOX-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens demethylation of DNA in some cell lines increases 15-LOX-1 expression. Increased levels of 15-LOX-1 are associated with downregulation of GATA-6 in Caco-2 colon cancer cells treated with sodium butyrate to induce cell differentiation and apoptosis. Activation of the cGMP-PKG system can induce the cellular expression of 15-LOX-1 in SW-480 colon cancer cells. 5-aza-2-deoxycytidine increases 15-LOX-1 expression. Interleukin-4 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines. Interleukin-13 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines up

General Information

General Information Comment Organism
metabolism shifting linoleic acid metabolism from 15-LOX-1 to COX-2 is procarcinogenic Homo sapiens
physiological function 15-LOX-1 promotes mitogenic response to epidermal growth factor in fibroblasts and NaBT-induced apoptosis in colon cancer cells. Non-steroidal anti-inflammatory drugs-induced apoptosis mediated by 15-LOX-1/GATA-6 in colon cancer Homo sapiens
physiological function inhibits tumour growth and metastasis. Enzyme promotes atherosclerosis and can inhibit growth and spread of lung (Lewis lung carcinoma model) and breast (mouse mammary adenocarcinoma model) cancer cells Mus musculus