Literature summary for 1.13.11.33 extracted from

Tang, Y.; Wang, M.T.; Chen, Y.; Yang, D.; Che, M.; Honn, K.V.; Akers, G.D.; Johnson, S.R.; Nie, D.
Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer (2009), Int. J. Cancer, 124, 1545-1551.

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Application

Application	Comment	Organism
medicine	15-LOX-2 is a negative regulator of tumor growth via downregulating angiogenesis	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed as a fusion protein with GFP (pEGFP-15LOX-2) in DU145 and PC-3 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	is absent in prostate cancer cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
15-lipoxygenase-2	-	Homo sapiens
15-LOX-2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	15-LOX-2 increases cell cycle arrest at G0/G1 phase. Injected into athymic nu/nu mice, prostate cancer cells with 15-LOX-2 expression can still form palpable tumors without significant changes in tumorigenicity. But, the tumors with 15-LOX-2 expression grow significantly slower than those derived from vector controls and are kept dormant for a long period of time. Increase in cell death in tumors derived from prostate cancer cells with 15- LOX-2 expression. 15-LOX-2 suppresses vascular endothelial growth factor A gene expression and sustains tumor dormancy in prostate cancer	Homo sapiens

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Release 2026.1 (March 2026)