Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | express both 15-LOX-1 and -2 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase-1 | - |
Homo sapiens |
15-lipoxygenase-2 | - |
Homo sapiens |
15-LOX-1 | - |
Homo sapiens |
15-LOX-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | 15-lipoxygenases may have chondroprotective properties by reducing metalloproteinase-1 and -13 expression. Their respective metabolites, 13(S)-hydroxy octadecadienoic and 15(S)-hydroxyeicosatetraenoic acids, suppress interleukin-1beta-induced metalloproteinase-1 and -13 expression in a PPARgamma-dependent pathway | Homo sapiens |