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Literature summary for 1.13.11.33 extracted from

  • Feltenmark, S.; Gautam, N.; Brunnstroem, A.; Griffiths, W.; Backman, L.; Edenius, C.; Lindbom, L.; Bjoerkholm, M.; Claesson, H.E.
    Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human Feltenmark, S.; Gautam, N.; Brunnstroem, A.; Griffiths, W.; Backman, L.; Edenius, C.; Lindbom, L.; Bjoerkholm, M.; Claesson, H.E.: Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells (2008), Proc. Natl. Acad. Sci. USA, 105, 680-685.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate the bifunctional enzyme also forms (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate, the product of 12-LO activity, EC 1.13.11.31, in a ratio of 9:1 15(S)-HPETE to 12(S)-HPETE, further reduced to the correspondent (S)-hydroxy fatty acids, in eosinophils, overview ?
additional information Homo sapiens eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in eosinophils and mast cells, metabolism of 14,15-leukotrienes in eosinophils, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme 15-LO-1
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell human umbilical vein endothelial cells, HUVEC Homo sapiens
-
eosinophil
-
 Homo sapiens
-
mast cell
-
 Homo sapiens
-
nasal polyp
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate the bifunctional enzyme also forms (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate, the product of 12-LO activity, EC 1.13.11.31, in a ratio of 9:1 15(S)-HPETE to 12(S)-HPETE, further reduced to the correspondent (S)-hydroxy fatty acids, in eosinophils, overview ?
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate the bifunctional enzyme also forms (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate, the product of 12-LO activity, EC 1.13.11.31, in a ratio of 9:1 15(S)-HPETE to 12(S)HPETE ?
additional information eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in eosinophils and mast cells, metabolism of 14,15-leukotrienes in eosinophils, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase-1
-
 Homo sapiens
15-LO-1
-
 Homo sapiens