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Literature summary for 1.13.11.33 extracted from

  • Gulliksson, M.; Brunnstroem, A.; Johannesson, M.; Backman, L.; Nilsson, G.; Harvima, I.; Dahlen, B.; Kumlin, M.; Claesson, H.
    Expression of 15-lipoxygenase type-1 in human mast cells (2007), Biochim. Biophys. Acta, 1771, 1156-1165.
    View publication on PubMed
Search for more literature for 1.13.11.33

Activating Compound

Activating Compound Comment Organism Structure
additional information interleukin-4 induces the expression of 15-LO-1 in cord blood derived mast cells, CBMC Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens 15-lipoxygenase type-1 is a prooxidant enzyme, which is expressed in asthmatic lungs leading to formation of pro- and anti-inflammatory mediators, overview (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate the product is further metabolized to 15(S)-hydroxyeicosatetranoic acid and 15-ketoeicosatetraenoic acid, the latter is the main product, pathway and mechanism, overview ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell from lungs of asthma patients, and from skin and cord blood Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2 15-lipoxygenase type-1 is a prooxidant enzyme, which is expressed in asthmatic lungs leading to formation of pro- and anti-inflammatory mediators, overview Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate the product is further metabolized to 15(S)-hydroxyeicosatetranoic acid and 15-ketoeicosatetraenoic acid, the latter is the main product, pathway and mechanism, overview ?
arachidonate + O2 immunohistochemic assay Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
15-lipoxygenase type-1
-
 Homo sapiens
15-LO-1
-
 Homo sapiens