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Literature summary for 1.13.11.33 extracted from

  • Assimes, T.L.; Knowles, J.W.; Priest, J.R.; Basu, A.; Borchert, A.; Volcik, K.A.; Grove, M.L.; Tabor, H.K.; Southwick, A.; Tabibiazar, R.; Sidney, S.; Boerwinkle, E.; Go, A.S.; Iribarren, C.; Hlatky, M.A.; Fortmann, S.P.; Myers, R.M.; Kuhn, H.; Risch, N.; Quertermous, T.
    A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease (2008), Atherosclerosis, 198, 136-144.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene ALOX15, DNA and amino acid sequence determination and analysis of wild-type and mutant T560M, promoter sequence analysis, genotyping, overview, expression of wild-type and mutant enzymes in Escherichia coli and HEK-297 cells, the mutant shows a low expression level in both systems compared to the wild-type enzyme Homo sapiens

Protein Variants

Protein Variants Comment Organism
T560M naturally occurring enzyme mutant, the mutant shows 20fold reduced catalytic activity, genotyping using 12974 samples, the haplotypes show increased risk of coronary artery disease compared to non-carriers, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P16050 gene ALOX15
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a bifunctional enzyme exhibiting 12-LO and 15-LO activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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 Homo sapiens
12/15-LO
-
 Homo sapiens