Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.33 extracted from

  • Kuehn, H.; Heydeck, D.; Brinckman, R.; Trebus, F.
    Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels (1999), Lipids, 34, S273-S279.
No PubMed abstract available
Search for more literature for 1.13.11.33

Inhibitors

Inhibitors Comment Organism Structure
13S-hydroperoxy-9E,11E-octadecydienoic acid rapidly inactivates Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Ca2+ for maximal intracellular activity, 12/15-lipoxygenases require a rise in cytosolic calcium concentration inducing a translocation of the enzyme from the cytosol to cellular membranes Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Mus musculus the enzyme is regulated pretranslational, translational and posttranslational (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 Homo sapiens the enzyme is regulated pretranslational, translational and posttranslational (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 Rattus norvegicus the enzyme is regulated pretranslational, translational and posttranslational (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 Oryctolagus cuniculus the enzyme is regulated pretranslational, translational and posttranslational (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 Mus musculus induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 Rattus norvegicus induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 Oryctolagus cuniculus induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
reticulocyte
-
 Oryctolagus cuniculus
-
reticulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2
-
 Rattus norvegicus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2
-
 Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 the enzyme is regulated pretranslational, translational and posttranslational Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 the enzyme is regulated pretranslational, translational and posttranslational Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 the enzyme is regulated pretranslational, translational and posttranslational Rattus norvegicus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 the enzyme is regulated pretranslational, translational and posttranslational Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression Rattus norvegicus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
arachidonate + O2 induction of experimental anemia leads to a systemic up-regulation of 12/15-lipoxygenases expression Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?