Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibitory: potassium cyanide or sodium azide | Cryptosporidium parvum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Cryptosporidium parvum | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
gel filtration | Cryptosporidium parvum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium parvum | Q5CV33 | - |
- |
Cryptosporidium parvum Iowa II | Q5CV33 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
84.3 | - |
substrate cumene hydroperoxide, 37°C, pH 7.6 | Cryptosporidium parvum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 glutathione + H2O2 | - |
Cryptosporidium parvum | glutathione disulfide + 2 H2O | - |
? | |
2 glutathione + H2O2 | - |
Cryptosporidium parvum Iowa II | glutathione disulfide + 2 H2O | - |
? | |
cumene hydroperoxide + 2 GSH | - |
Cryptosporidium parvum | 2-phenylpropan-2-ol + GSSG + H2O | - |
? | |
cumene hydroperoxide + 2 GSH | - |
Cryptosporidium parvum Iowa II | 2-phenylpropan-2-ol + GSSG + H2O | - |
? | |
additional information | enzyme shows substrate preference against organic hydroperoxides, such as cumene-OOH and t-butyl-OOH, and low activity against H2O2 | Cryptosporidium parvum | ? | - |
? | |
additional information | enzyme shows substrate preference against organic hydroperoxides, such as cumene-OOH and t-butyl-OOH, and low activity against H2O2 | Cryptosporidium parvum Iowa II | ? | - |
? | |
tert-butyl hydroperoxide + 2 GSH | - |
Cryptosporidium parvum | tert-butyl alcohol + GSSG + H2O | - |
? | |
tert-butyl hydroperoxide + 2 GSH | - |
Cryptosporidium parvum Iowa II | tert-butyl alcohol + GSSG + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 24800, calculated, 1 * 25000, SDS-PAGE | Cryptosporidium parvum |
Synonyms | Comment | Organism |
---|---|---|
cgd3_460 | - |
Cryptosporidium parvum |
Organism | Comment | Expression |
---|---|---|
Cryptosporidium parvum | the GPx gene contains a standard UGU codon for cysteine instead of a UGA opal codon for seleno-cysteine at the active site, and no selenoocysteine insertion sequence motif is identified within the 3'-untranslated region | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme effectively protects DNA and protein from oxidative damage induced by hydrogen peroxide | Cryptosporidium parvum |