Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + O2 | Streptococcus cristatus | - |
pyruvate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus cristatus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the enzyme is expressed throughout the growth phase, and expression of the lox gene increases by about 2.5fold when cells enter the stationary phase | Streptococcus cristatus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + O2 | - |
Streptococcus cristatus | pyruvate + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lactate oxidase | - |
Streptococcus cristatus |
LOX | - |
Streptococcus cristatus |
General Information | Comment | Organism |
---|---|---|
metabolism | inactivation of gene pox encoding pyruvate oxidase causes a dramatic reduction in H2O2 production from lactate, suggesting a synergistic action of the two oxidases in converting lactate into H2O2. The pox mutant of Streptomyces oligofermentans fails to inhibit Streptomyces mutans even though lox is active | Streptococcus cristatus |
physiological function | H2O2 production, especially lactate oxidase, allows Streptomyces oligofermentans to out-compete Streptomyces mutans in oral commensals, the enzyme mainly contributes to H2O2 production in stationary phase. But lactate oxidase requires cofunction of pyruvate oxidase for successfully inhibiting Streptomyces mutans | Streptococcus cristatus |