Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the JNK inhibitor SP600125 has no effect on 11beta-HSD2 enzyme activity | Homo sapiens | |
U0126 | the ERK1/2 inhibitor activates 11beta-HSD2 enzyme activity 3fold | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene HSD11B2, two-step real-time quantitative RT-PCR isozyme 11beta-HSD2 expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | the ERK1/2 inhibitor U0126 can block cadmium-induced inhibition of placental 11beta-HSD2. Cadmium does not alter activities of p38 MAPK, JNK, or PI3 kinase. Cadmium specifically activates the ERK1/2 signaling pathway in human trophoblast cells | Homo sapiens | |
additional information | the JNK inhibitor SP600125 has no effect on 11beta-HSD2 enzyme activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P80365 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
trophoblast | placental trophoblast cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Hsd11B2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of placental 11beta-HSD2 is regulated at both transcriptional and posttranscriptional levels. JNK inhibitor SP600125 has no effect on 11beta-HSD2 isozyme expression | additional information |
Homo sapiens | p38 MAPK enhances placental 11beta-HSD2 expression by a posttranscriptional mechanism. ERK1/2 inhibitor U0126 induces the enzyme expression in trophoblasts. siRNA-mediated knockdown of ERK1/2 expression leads to a similar increase in levels of 11beta-HSD2 protein, as seen in cells treated with the ERK1/2 pharmacological inhibitor | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays a key role in fetal development. p38 MAPK is a positive regulator of placental 11beta-HSD2, p38 MAPK upregulates placental 11b-HSD2 by increasing the half-life of 11beta-HSD2 mRNA. Also ERK1/2 signaling is involved in regulation of placental 11beta-HSD2, ERK1/2 inhibitor U0126 induces the enzyme expression in trophoblasts. siRNA-mediated knockdown of ERK1/2 expression leads to a similar increase in levels of 11beta-HSD2 protein, as seen in cells treated with the ERK1/2 pharmacological inhibitor | Homo sapiens |