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Literature summary for 1.1.1.79 extracted from

  • Zong, C.; Nie, X.; Zhang, D.; Ji, Q.; Qin, Y.; Wang, L.; Jiang, D.; Gong, C.; Liu, Y.; Zhou, G.
    Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis (2016), Pathol. Res. Pract., 212, 365-371.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glycerate + NAD+ Homo sapiens
-
 hydroxypyruvate + NADH + H+
-
 ?
glycolate + NADP+ Homo sapiens
-
 glyoxylate + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBQ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
HT-29 cell cultured with tumor necrosis factor alpha Homo sapiens
-
intestinal epithelial cell
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glycerate + NAD+
-
 Homo sapiens hydroxypyruvate + NADH + H+
-
 ?
glycolate + NADP+
-
 Homo sapiens glyoxylate + NADPH + H+
-
 r

Synonyms

Synonyms Comment Organism
glyoxylate reductase/hydroxypyruvate reductase
-
 Homo sapiens
GRHPR bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities Homo sapiens
GRHPR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) by trinitrobenzenesulphonic acid, which induces experimental colitis and intestinal epithelial cell apoptosis up

General Information

General Information Comment Organism
malfunction enzyme deficiency is the underlying cause of primary hyperoxaluria type 2 (PH2) and leads to increased urinary oxalate levels, formation of kidney stones and renal failure. Upregulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis, the phenomenon also occurs in patients with Crohn's disease. Overexpression of GRHPR is accompanied by active caspase-3 and cleaved poly ADP-ribose polymerase (PARP) accumulation. Knockdown of GRHPR inhibits the accumulation of active caspase-3 and cleaved PARP in TNF-alpha treated HT-29 cells Homo sapiens
physiological function upregulation of glyoxylate reductase/hydroxypyruvate reductase is associated with intestinal epithelial cells apoptosis in trinitrobenzenesulfonic acid-induced colitis Homo sapiens
physiological function human glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a D-2 hydroxy-acid dehydrogenase that plays a critical role in the removal of the metabolic by-product glyoxylate from the liver Homo sapiens