Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-1-aminopropan-2-ol | competitive | Escherichia coli | |
3-chloromercuribenzoate | complete inhibition at 0.05 mM | Escherichia coli | |
8-hydroxyquinoline | nearly complete inhibition at 2.5 mM | Escherichia coli | |
D,L-1,3-diaminopropan-2-ol | - |
Escherichia coli | |
D,L-2hydroxy-2-phenylethylamine | - |
Escherichia coli | |
D,L-serine | - |
Escherichia coli | |
iodoacetate | more inhibitory in intact cells than in cell free extracts | Escherichia coli | |
L-1-(3,4-dihydroxyphenyl)-2-aminoethanol | noradrenalin | Escherichia coli | |
sodium carbonate/dicarbonate buffers | at alkaline pH | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
NAD+ | at pH 7 with aminopropanol as substrate | Escherichia coli | |
0.4 | - |
NAD+ | at pH 9.6 with aminopropanol as substrate | Escherichia coli | |
1.5 | - |
L-1-Aminopropan-2-ol | cell free extracts | Escherichia coli | |
10 | - |
D,L-1-aminopropan-2-ol | cell free extracts | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-1-aminopropan-2-ol + NAD+ | Escherichia coli | involved in L-threonine and vitamin B12 pathway | aminoacetone + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.008 | - |
cell free extract | Escherichia coli |
Storage Stability | Organism |
---|---|
-15°C stable for several days | Escherichia coli |
0-5°C significant loss in activity | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D,L-1-aminopropan-2-ol + NAD+ | more active with L-enantiomer, activity with D-enantiomer might be due to D-aminopropanol specific enzyme | Escherichia coli | aminoacetone + NADH | - |
? | |
D,L-aminobutan-2-ol + NAD+ | - |
Escherichia coli | 1-amino-2-oxobutane + NADH | - |
? | |
D,L-phenylserine + NAD+ | - |
Escherichia coli | ? | - |
? | |
L-1-aminopropan-2-ol + NAD+ | - |
Escherichia coli | aminoacetone + NADH | - |
? | |
L-1-aminopropan-2-ol + NAD+ | involved in L-threonine and vitamin B12 pathway | Escherichia coli | aminoacetone + NADH | - |
? | |
L-1-aminopropan-2-ol + NADP+ | - |
Escherichia coli | aminoacetone + NADPH | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
cell free extract, second peak at pH 7.0-7.2 | Escherichia coli |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 10 | two peaks at pH 7 and 10 with very low activity at pH 8.5, at pH 7 50% of maximum activity | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | required | Escherichia coli | |
NADP+ | poor substitute for NAD+ | Escherichia coli |