Activating Compound | Comment | Organism | Structure |
---|---|---|---|
vitamin D3 | activates oxidative activity in HCT8 and LoVo cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
vitamin D3 | inhibits reductive activity in HCT8 and LoVo cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-3,17-dione + NADPH + H+ | Homo sapiens | 17beta-HSD3 and 5, formation of active androgens in testis and prostate | testosterone + NADP+ | - |
? | |
estradiol-17beta + NADP+ | Homo sapiens | 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity | estrone + NADPH | - |
? | |
estrone + NADPH + H+ | Homo sapiens | 17beta-HSD1, final step in the synthesis of active estrogens | estradiol-17beta + NADP+ | - |
? | |
testosterone + NADP+ | Homo sapiens | 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens | 4-androstene-3,17-dione + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms 1-4, 17beta-HSD 1-4 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ | 5 isoforms with different substrate specificities and tissue distribution, 17beta-HSD1 predominantly catalyzes the reaction of estrone to estradiol-17beta, 17beta-HSD2 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD3 and 5 catalyzes the reaction of androstenedione to testosterone, 17beta-HSD4 catalyzes the reaction of estradiol-17beta to estrone with low substrate affinty | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
DLD-1 cell | cultured cells, expresses 17beta-HSD isoforms 1-4 | Homo sapiens | - |
HCT-116 cell | cultured cells, expresses 17beta-HSD isoforms 1-4 | Homo sapiens | - |
HCT-8 cell | cultured cells, expresses 17beta-HSD isoforms 1-4 | Homo sapiens | - |
LoVo cell | cultured cells, expresses 17beta-HSD isoforms 1-4 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-3,17-dione + NADPH + H+ | 17beta-HSD3 and 5, formation of active androgens in testis and prostate | Homo sapiens | testosterone + NADP+ | - |
? | |
estradiol-17beta + NADP+ | 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity | Homo sapiens | estrone + NADPH | - |
? | |
estradiol-17beta + NADP+ | reverse reaction catalyzed by different isoforms of the enzyme | Homo sapiens | estrone + NADPH | - |
? | |
estrone + NADPH + H+ | 17beta-HSD1, final step in the synthesis of active estrogens | Homo sapiens | estradiol-17beta + NADP+ | - |
? | |
estrone + NADPH + H+ | reverse reaction catalyzed by different isoforms of the enzyme | Homo sapiens | estradiol-17beta + NADP+ | - |
? | |
testosterone + NADP+ | 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens | Homo sapiens | 4-androstene-3,17-dione + NADPH + H+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |