KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000142 | - |
cortisone | 28°C, pH not specified in the publication | Danio rerio |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Danio rerio | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | th enzyme is expressed throughout the whole embryonic development | Danio rerio | - |
gill | high expression | Danio rerio | - |
gonad | high expression | Danio rerio | - |
intestine | high expression | Danio rerio | - |
kidney | high expression | Danio rerio | - |
liver | high expression | Danio rerio | - |
additional information | in adult tissues 20beta-HSD type 2 shows a ubiquitous expression pattern with some minor sex-specific differences | Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | no activity with NAD+ | Danio rerio | 20beta-hydroxycortisone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20beta-HSD type 2 | - |
Danio rerio |
20beta-hydroxysteroid dehydrogenase type 2 | - |
Danio rerio |
SDR12C55 | - |
Danio rerio |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | no activity with NAD+ | Danio rerio |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme mediates glucocorticoid catabolism in fish, important enzyme in cortisol catabolism | Danio rerio |