General Stability | Organism |
---|---|
NADP+ stabilizes, while the enzyme is rapidly inactivated in presence of substrate glucose 6-phosphate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Rattus norvegicus | |
ATP | - |
Rattus norvegicus | |
p-chloromercuribenzoate | can be reversed 100% by dithiothreitol, partially by glutathione | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
NADP+ | 0.0025 mM glucose 6-phosphate | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
62000 | - |
2 * 62000, SDS-PAGE | Rattus norvegicus |
121000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O + NADP+ | Rattus norvegicus | - |
D-gluconate 6-phosphate + NADPH + H+ | - |
? | |
additional information | Rattus norvegicus | physiological regulation of NADP+-NADPH-ratio in the brain is dicussed | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
480 | - |
purified enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O + NADP+ | - |
Rattus norvegicus | D-gluconate 6-phosphate + NADPH + H+ | - |
? | |
D-glucose 6-phosphate + H2O + NADP+ | - |
Rattus norvegicus | D-gluconate 6-phosphate + NADPH + H+ | - |
ir | |
additional information | physiological regulation of NADP+-NADPH-ratio in the brain is dicussed | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 62000, SDS-PAGE | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Rattus norvegicus |