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Literature summary for 1.1.1.44 extracted from

  • Liu, R.; Li, W.; Tao, B.; Wang, X.; Yang, Z.; Zhang, Y.; Wang, C.; Liu, R.; Gao, H.; Liang, J.; Yang, W.
    Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance (2019), Nat. Commun., 10, 991 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.44

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52209
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Y481 phosphorylation is essential for epidermal growth factor receptor (EGFR) activation-enhanced 6PGD activity Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
GSC11 cell infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD) Homo sapiens
-
U-251MG cell stably expressing epidermal growth factor receptor (EGFR), infected with the lentivirus expressing Flag tagged 6PGD (Flag-6PGD) Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
 Homo sapiens
6PGD
-
 Homo sapiens

General Information

General Information Comment Organism
drug target abrogating 6-phosphogluconate dehydrogenase Y481 phosphorylation (pY481) dramatically attenuates epidermal growth factor receptor(EGF) promotes glioma cell proliferation, tumor growth and resistance to ionizing radiation. 6PGD pY481 is associated with Fyn expression, the malignancy and prognosis of human glioblastoma. Critical role of Fyn-dependent 6-phosphogluconate dehydrogenase (6PGD) phosphorylation in EGF-promoted tumor growth and radiation resistance Homo sapiens
metabolism upon epidermal growth factor receptor (EGFR) activation, the enzyme (6PGD) is phosphorylated at tyrosine 481 by Src family kinase Fyn. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP+ and therefore activates the pentose phosphate pathway for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis Homo sapiens
physiological function the enzyme is commonly upregulated and plays important roles in many human cancers Homo sapiens