BRENDA - Enzyme Database
show all sequences of 1.1.1.361

A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis

Vetter, N.D.; Langill, D.M.; Anjum, S.; Boisvert-Martel, J.; Jagdhane, R.C.; Omene, E.; Zheng, H.; van Straaten, K.E.; Asiamah, I.; Krol, E.S.; Sanders, D.A.; Palmer, D.R.; J. Am. Chem. Soc. 135, 5970-5973 (2013)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression in Escherichia coli
Bacillus subtilis
Organism
Organism
UniProt
Commentary
Textmining
Bacillus subtilis
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
D-glucose + NAD+
poor substrate
725212
Bacillus subtilis
3-dehydro-D-glucose + NADH + H+
-
-
-
?
D-glucose 6-phosphate + NAD+
-
725212
Bacillus subtilis
3-dehydro-D-glucose 6-phosphate + NADH + H+
-
-
-
?
inositol + NAD+
poor substrate
725212
Bacillus subtilis
? + NADH + H+
-
-
-
?
additional information
no substrate: UDP-glucose
725212
Bacillus subtilis
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
ntdC
-
Bacillus subtilis
yhjJ
-
Bacillus subtilis
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
no cofactor: NADP+
Bacillus subtilis
NAD+
highly specific
Bacillus subtilis
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Bacillus subtilis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
no cofactor: NADP+
Bacillus subtilis
NAD+
highly specific
Bacillus subtilis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
D-glucose + NAD+
poor substrate
725212
Bacillus subtilis
3-dehydro-D-glucose + NADH + H+
-
-
-
?
D-glucose 6-phosphate + NAD+
-
725212
Bacillus subtilis
3-dehydro-D-glucose 6-phosphate + NADH + H+
-
-
-
?
inositol + NAD+
poor substrate
725212
Bacillus subtilis
? + NADH + H+
-
-
-
?
additional information
no substrate: UDP-glucose
725212
Bacillus subtilis
?
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
the ntd operon is essential for biosynthesis of the unusual disaccharide 3,3'-neotrehalosadiamine. The enzymes catalyze the biosynthesis of kanosamine from D-glucose 6-phosphate. NtdC is a D-glucose-6-phosphate-3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase, and NtdB is a kanosamine-6-phosphate phosphatase
Bacillus subtilis
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the ntd operon is essential for biosynthesis of the unusual disaccharide 3,3'-neotrehalosadiamine. The enzymes catalyze the biosynthesis of kanosamine from D-glucose 6-phosphate. NtdC is a D-glucose-6-phosphate-3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase, and NtdB is a kanosamine-6-phosphate phosphatase
Bacillus subtilis
Other publictions for EC 1.1.1.361
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725212
Vetter
A previously unrecognized kano ...
Bacillus subtilis
J. Am. Chem. Soc.
135
5970-5973
2013
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