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Literature summary for 1.1.1.291 extracted from
- Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri (2006), Proc. Natl. Acad. Sci. USA, 103, 12341-12346.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Eubacterium barkeri |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
NAD+ | - |
Eubacterium barkeri |  |
| 1.1 | - |
2-hydroxymethylglutarate | - |
Eubacterium barkeri | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
4 * 32000, SDS-PAGE | Eubacterium barkeri |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-formylglutarate + NADH + H+ | Eubacterium barkeri | the enzyme forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri | 2-hydroxymethylglutarate + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Eubacterium barkeri | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| instability under anaerobic conditions | Eubacterium barkeri |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Eubacterium barkeri |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-formylglutarate + NADH + H+ | the enzyme forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri | Eubacterium barkeri | 2-hydroxymethylglutarate + NAD+ | - |
? | |
| 2-hydroxymethylglutarate + NAD+ | - |
Eubacterium barkeri | 2-formylglutarate + NADH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 32000, SDS-PAGE | Eubacterium barkeri |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HgD | - |
Eubacterium barkeri |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | no activity with NADP+ | Eubacterium barkeri | |
| NADH | - |
Eubacterium barkeri | |
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