Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is induced by nitric aoxide | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by nitric oxide | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + NADH + H+ | Staphylococcus aureus | the nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity, L-lactate production allows Staphylococcus aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence, regulation, overview | (S)-lactate + NAD+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
gene ldh1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | metabolic adaptation of Staphylococcus aureus to nitrosative stress, overview | Staphylococcus aureus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + NADH + H+ | - |
Staphylococcus aureus | (S)-lactate + NAD+ | - |
r | |
pyruvate + NADH + H+ | the nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity, L-lactate production allows Staphylococcus aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence, regulation, overview | Staphylococcus aureus | (S)-lactate + NAD+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
lactate dehydrogenase | - |
Staphylococcus aureus |
LDH | - |
Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Staphylococcus aureus | |
NADH | - |
Staphylococcus aureus |