Application | Comment | Organism |
---|---|---|
drug development | LDH is critically implicated in tumor growth and therefore considered to be an important target protein for antitumor metal complexes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu[Ac]2[2,2'-bipyridine] | analysis of interaction with the LDH isozymes and their modulation, significantly inhibits LDH in liver, kidney, heart, spleen, brain and skeletal muscle tissues, overview | Mus musculus | |
Zn[Ac]2[2,2'-bipyridine] | analysis of interaction with the LDH isozymes and their modulation, significantly inhibits LDH in liver, kidney, and heart, but not in spleen, brain and skeletal muscle tissues, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | LDH-A | Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + NAD+ | Mus musculus | - |
pyruvate + NADH + H+ | - |
r | |
(S)-lactate + NAD+ | Mus musculus AKR | - |
pyruvate + NADH + H+ | - |
r | |
additional information | Mus musculus | LDH is critically implicated in tumor growth | ? | - |
? | |
additional information | Mus musculus AKR | LDH is critically implicated in tumor growth | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus AKR | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | differential expressions of LDH isozymes in different types of tumors | Mus musculus | - |
heart | H-type isozyme | Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
muscle | M-type isozyme | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + NAD+ | - |
Mus musculus | pyruvate + NADH + H+ | - |
r | |
(S)-lactate + NAD+ | - |
Mus musculus AKR | pyruvate + NADH + H+ | - |
r | |
additional information | LDH is critically implicated in tumor growth | Mus musculus | ? | - |
? | |
additional information | LDH is critically implicated in tumor growth | Mus musculus AKR | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LDH | - |
Mus musculus |
LDH-A | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus | |
NADH | - |
Mus musculus |