Activating Compound | Comment | Organism | Structure |
---|---|---|---|
sorbitol | 600 mosmol per kg H2O, up to 2fold increase in activity | Rattus norvegicus | |
SP-600125 | 0.01 mM, about 50% increase of sorbitol-induced activity | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | inhibition of enzyme by zolrestat attenuates apoptosis in sorbitol-treated cells. Hyperosmolarity-induced cell death requires induction of enzyme as well as a decrease in intracellular glutathione levels | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ly-294002 | 0.05 mM, little decrease in sorbitol-induced activity | Rattus norvegicus | |
PD-98059 | 0.05 mM, decrease of sorbitol-induced activity to control level | Rattus norvegicus | |
SB-203580 | 0 0.01 mM, decrease of sorbitol-induced activity below control level | Rattus norvegicus | |
zopolrestat | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | cultured cardiomyocyte | Rattus norvegicus | - |