Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Mus musculus | |
additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Homo sapiens | |
interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADP+ | Mus musculus | - |
11-dehydrocorticosterone + NADPH | - |
ir | |
corticosterone + NADP+ | Homo sapiens | - |
11-dehydrocorticosterone + NADPH | - |
ir | |
cortisone + NADPH + H+ | Mus musculus | - |
cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Mus musculus | - |
adipose tissue | - |
Homo sapiens | - |
aortic smooth muscle cell | - |
Mus musculus | - |
aortic smooth muscle cell | - |
Homo sapiens | - |
colon | - |
Mus musculus | - |
colon | - |
Homo sapiens | - |
granulosa cell | - |
Mus musculus | - |
granulosa cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
lymph node | peripheral lymph nodes and mesenteric lymph nodes | Mus musculus | - |
MG-63 cell | - |
Mus musculus | - |
MG-63 cell | - |
Homo sapiens | - |
additional information | human monocytes do not express 11beta-HSD1 | Mus musculus | - |
additional information | human monocytes do not express 11beta-HSD1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADP+ | - |
Mus musculus | 11-dehydrocorticosterone + NADPH | - |
ir | |
corticosterone + NADP+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADPH | - |
ir | |
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus | |
NADP+ | - |
Homo sapiens |