Cloned (Comment) | Organism |
---|---|
expression in Pichia pastoris | Rattus norvegicus |
expression Pichia pastoris | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
cortisone | 37°C, pH 7.4, recombinant 11beta-HSD1 | Homo sapiens | |
0.0017 | - |
cortisol | 37°C, pH 7.4, recombinant 11beta-HSD1 | Homo sapiens | |
0.0025 | - |
11-Dehydrocorticosterone | 37°C, pH 7.4, recombinant 11beta-HSD1 | Rattus norvegicus | |
0.003 | - |
corticosterone | 37°C, pH 7.4, recombinant 11beta-HSD1 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
membrane | attached to the membrane facing the luminal compartment | Homo sapiens | 16020 | - |
membrane | attached to the membrane facing the luminal compartment | Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADP+ | Rattus norvegicus | bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo | 11-dehydrocorticosterone + NADPH + H+ | - |
r | |
cortisone + NADPH + H+ | Homo sapiens | bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo | cortisol + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
glycoprotein | - |
Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADP+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADPH + H+ | - |
r | |
corticosterone + NADP+ | bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo | Rattus norvegicus | 11-dehydrocorticosterone + NADPH + H+ | - |
r | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | bidirectional in vitro, believed to predominantly function as an oxidoreductase in vivo | Homo sapiens | cortisol + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD1 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |