Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxybutyryl-CoA | noncompetitive product inhibition pattern | Mycobacterium tuberculosis | |
NADP+ | noncompetitive product inhibition pattern | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | detailed kinetic and thermodynamic analysis, solvent and multiple kinetic isotope effects, kinetic mechanism | Mycobacterium tuberculosis | |
0.026 | - |
NADPH | pH 7.6, 30°C | Mycobacterium tuberculosis | |
0.165 | - |
acetoacetyl-CoA | pH 7.6, 30°C | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-oxoacyl-[acyl-carrier protein] + NADPH | Mycobacterium tuberculosis | - |
3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
gene mabA | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+ | chemical and kinetic mechanism | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-oxoacyl-[acyl-carrier protein] + NADPH | - |
Mycobacterium tuberculosis | 3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
r | |
acetoacetyl-CoA + NADPH | - |
Mycobacterium tuberculosis | 3-hydroxybutyryl-CoA + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ACP reductase | - |
Mycobacterium tuberculosis |
beta-ketoacyl-acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
MabA | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mycobacterium tuberculosis |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
15 | 37 | temperature profile | Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7 | - |
acetoacetyl-CoA | pH 7.0, 25°C | Mycobacterium tuberculosis | |
7 | - |
NADPH | pH 7.6, 30°C | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mycobacterium tuberculosis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.8 | 10 | pH profile, pH-dependence analysis, overview | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mycobacterium tuberculosis | |
NADPH | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | product inhibition kinetics, overview | Mycobacterium tuberculosis |