Disease on EC 5.6.1.1 - microtubule-severing ATPase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenocarcinoma
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Adenocarcinoma of Lung
The lncRNA MALAT1/miR-30/Spastin Axis Regulates Hippocampal Neurite Outgrowth.
Amyotrophic Lateral Sclerosis
Heterozygous S44L missense change of the spastin gene in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Spastin mutations in sporadic adult-onset upper motor neuron syndromes.
Astrocytoma
Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation.
Ataxia
Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis.
Azoospermia
Lack of association of KATNAL1 gene sequence variants and azoospermia in humans.
Breast Neoplasms
Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer.
Breast Neoplasms
Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer.
Breast Neoplasms
Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer.
Breast Neoplasms
Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.
Breast Neoplasms
Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
Carcinogenesis
Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis.
Carcinogenesis
The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol.
Carcinoma
Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.
Carcinoma
Suppression of scinderin modulates epithelial?mesenchymal transition markers in highly metastatic gastric cancer cell line SGC?7901.
Carcinoma, Hepatocellular
Downregulation of Kinesin spindle protein inhibits proliferation, induces apoptosis and increases chemosensitivity in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Scinderin is a novel transcriptional target of BRMS1 involved in regulation of hepatocellular carcinoma cell apoptosis.
Carcinoma, Hepatocellular
Scinderin suppresses cell proliferation and predicts the poor prognosis of hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
Cerebellar Ataxia
A Japanese family with a novel nonsense mutation in the spastin gene associated with both cerebellar ataxia and cognitive impairment.
Cerebellar Ataxia
Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation.
Colorectal Neoplasms
Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer.
Congenital Abnormalities
Association between an alternative promoter polymorphism and sperm deformity rate is due to modulation of the expression of KATNAL1 transcripts in Chinese Holstein bulls.
Decompression Sickness
Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
Dementia
Dementia in SPG4 hereditary spastic paraplegia: clinical, genetic, and neuropathologic evidence.
Dermatitis
A newly recognized 13q12.3 microdeletion syndrome characterized by intellectual disability, microcephaly, and eczema/atopic dermatitis encompassing the HMGB1 and KATNAL1 genes.
Developmental Dysplasia of the Hip
Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.
Epilepsy
A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members.
Epilepsy
A novel phenotype of 13q12.3 microdeletion characterized by epilepsy in an Asian child: a case report.
Epilepsy
Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis.
Epilepsy
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Gait Disorders, Neurologic
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.
Genetic Diseases, Inborn
A new case of 13q12.2q13.1 microdeletion syndrome contributes to phenotype delineation.
Genetic Diseases, Inborn
Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knock-out mice.
Glioblastoma
Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation.
Head and Neck Neoplasms
Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.
Hematologic Neoplasms
IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies.
Infections
Klebsiella pneumoniae Redistributes Katanin Severing Proteins and Alters Astral Microtubules during Mitosis.
Infertility
KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.
Infertility
Lack of association of KATNAL1 gene sequence variants and azoospermia in humans.
Infertility
Molecular Modeling and Dynamics Simulation Analysis of KATNAL1 for Identification of Novel Inhibitor of Sperm Maturation.
Infertility, Male
An essential role for katanin p80 and microtubule severing in male gamete production.
Intellectual Disability
A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.
Intellectual Disability
A newly recognized 13q12.3 microdeletion syndrome characterized by intellectual disability, microcephaly, and eczema/atopic dermatitis encompassing the HMGB1 and KATNAL1 genes.
Leukemia
Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.
Leukemia, Myeloid
A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias.
Lissencephaly
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
Lung Neoplasms
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
Lung Neoplasms
Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients.
Lung Neoplasms
Optimized S-Trityl-l-cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
Lung Neoplasms
Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin.
Lymphatic Metastasis
Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics.
Lymphatic Metastasis
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
Lymphatic Metastasis
Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients.
Lymphatic Metastasis
Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer.
Lymphatic Metastasis
Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
Lymphoma
A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies.
Lymphoma
The Addition of G-CSF Shifts the Dose Limiting Toxicity (DLT) and Markedly Increases the Maximum Tolerated Dose (MTD) and Activity of the Kinesin Spindle Protein Inhibitor SB-743921in Patients with Relapsed or Refractory Lymphoma: Results of an International, Multicenter Phase I/II Study.
Lymphoma, B-Cell
The novel kinesin spindle protein (KSP) inhibitor SB-743921 exhibits marked activity in in vivo and in vitro models of aggressive large B-cell lymphoma.
Malformations of Cortical Development
Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors.
Melanoma
A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial.
Memory Disorders
Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits.
Microcephaly
A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.
Microcephaly
A newly recognized 13q12.3 microdeletion syndrome characterized by intellectual disability, microcephaly, and eczema/atopic dermatitis encompassing the HMGB1 and KATNAL1 genes.
Microcephaly
Katanin p80 regulates human cortical development by limiting centriole and cilia number.
microtubule-severing atpase deficiency
Graded Control of Microtubule Severing by Tubulin Glutamylation.
microtubule-severing atpase deficiency
Katanin regulates dynamics of microtubules and biogenesis of motile cilia.
microtubule-severing atpase deficiency
Suppression of spastin Mutant Phenotypes by Pak3 Loss Implicates a Role for Reactive Glia in AD-HSP.
Motor Neuron Disease
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.
Motor Neuron Disease
Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle.
Motor Neuron Disease
Spastin mutations in sporadic adult-onset upper motor neuron syndromes.
Multiple Myeloma
A phase 1 dose-escalation study of filanesib plus bortezomib and dexamethasone in patients with recurrent/refractory multiple myeloma.
Multiple Myeloma
Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update.
Multiple Myeloma
Filanesib in combination with pomalidomide and dexamethasone in refractory MM patients: safety and efficacy, and association with alpha 1-acid glycoprotein (AAG) levels. Phase Ib/II Pomdefil clinical trial conducted by the Spanish MM group.
Multiple Myeloma
Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520.
Multiple Myeloma
The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma.
Multiple Sclerosis
A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members.
Muscle Spasticity
Identification of a novel mutation in the spastin gene (SPG4) in an Italian family with hereditary spastic paresis.
Muscle Spasticity
Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations.
Muscular Atrophy
Effect of exogenous spastin combined with polyethylene glycol on sciatic nerve injury.
Muscular Dystrophies
A new double-trouble phenotype: fascioscapulohumeral muscular dystrophy ameliorates hereditary spastic paraparesis due to spastin mutation.
Neoplasm Metastasis
Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer.
Neoplasm Metastasis
Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics.
Neoplasm Metastasis
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
Neoplasm Metastasis
Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients.
Neoplasm Metastasis
Katanin P80 expression correlates with lymph node metastasis and worse overall survival in patients with breast cancer.
Neoplasm Metastasis
Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.
Neoplasm Metastasis
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Neoplasm Metastasis
Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
Neoplasms
A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study.
Neoplasms
A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors.
Neoplasms
A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours.
Neoplasms
A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors.
Neoplasms
A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies.
Neoplasms
ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models.
Neoplasms
Bioengineered bacterial outer membrane vesicles as cell-specific drug-delivery vehicles for cancer therapy.
Neoplasms
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.
Neoplasms
Delivery of kinesin spindle protein targeting siRNA in solid lipid nanoparticles to cellular models of tumor vasculature.
Neoplasms
Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein.
Neoplasms
Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics.
Neoplasms
Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs.
Neoplasms
Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.
Neoplasms
Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis.
Neoplasms
First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors.
Neoplasms
First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement.
Neoplasms
Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells.
Neoplasms
Intratumoral electro-transfer of small interfering RNA against kinesin spindle protein (KSP) slows down tumor progression.
Neoplasms
Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.
Neoplasms
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
Neoplasms
Katanin P80 correlates with larger tumor size, lymph node metastasis, and advanced TNM stage and predicts poor prognosis in non-small-cell lung cancer patients.
Neoplasms
Kinesin Spindle Protein (KSP) Inhibitors in Combination with Chemotherapeutic Agents for Cancer Therapy.
Neoplasms
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
Neoplasms
KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer.
Neoplasms
LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin.
Neoplasms
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Neoplasms
Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520.
Neoplasms
Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation.
Neoplasms
Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy.
Neoplasms
Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.
Neoplasms
PEGylated DC-Chol/DOPE cationic liposomes containing KSP siRNA as a systemic siRNA delivery Carrier for ovarian cancer therapy.
Neoplasms
Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.
Neoplasms
Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5.
Neoplasms
Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.
Neoplasms
Scinderin-knockdown inhibits proliferation and promotes apoptosis in human breast carcinoma cells.
Neoplasms
Simultaneous silencing of VEGF and KSP by siRNA cocktail inhibits proliferation and induces apoptosis of hepatocellular carcinoma Hep3B cells.
Neoplasms
Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes.
Neoplasms
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Neoplasms
Suppression of scinderin modulates epithelial?mesenchymal transition markers in highly metastatic gastric cancer cell line SGC?7901.
Neoplasms
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.
Neoplasms
Systemic delivery of CRISPR/Cas9 to hepatic tumors for cancer treatment using altered tropism of lentiviral vector.
Neoplasms
The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma.
Neoplasms
Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
Neoplasms
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases.
Neoplasms
[Antitumor activity of novel tetrahydro-beta-carboline derivatives as KSP inhibitors].
Nervous System Diseases
The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.
Neurodegenerative Diseases
Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia.
Neurodegenerative Diseases
Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system.
Neurodegenerative Diseases
Identification of the Drosophila melanogaster homolog of the human spastin gene.
Neurodegenerative Diseases
Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia.
Neurodegenerative Diseases
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.
Neurodegenerative Diseases
Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor.
Neurodegenerative Diseases
Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation.
Neurodegenerative Diseases
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.
Ovarian Neoplasms
Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor.
Paralysis
?he Nematicidal Potential of Bioactive Streptomyces Strains Isolated from Greek Rhizosphere Soils Tested on Arabidopsis Plants of Varying Susceptibility to Meloidogyne spp.
Paraparesis
Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations.
Paraparesis, Spastic
A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members.
Paraparesis, Spastic
A new double-trouble phenotype: fascioscapulohumeral muscular dystrophy ameliorates hereditary spastic paraparesis due to spastin mutation.
Paraparesis, Spastic
Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation.
Paraparesis, Spastic
Clinical features of hereditary spastic paraplegia due to spastin mutation.
Paraparesis, Spastic
Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutation.
Paraparesis, Spastic
Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.
Paraparesis, Spastic
Infantile hereditary spastic paraparesis due to codominant mutations in the spastin gene.
Paraparesis, Spastic
Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin gene.
Paraparesis, Spastic
Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis.
Paraparesis, Spastic
Novel spastin mutations and their expression analysis in two Italian families.
Paraparesis, Spastic
Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations.
Paraparesis, Spastic
Spastin and paraplegin gene analysis in selected cases of motor neurone disease (MND).
Paraparesis, Spastic
Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases.
Paraparesis, Spastic
Spastin mutations in sporadic adult-onset upper motor neuron syndromes.
Paraparesis, Spastic
The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.
Paraplegia
A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.
Paraplegia
A novel insertion mutation in spastin gene is the cause of spastic paraplegia in a Chinese family.
Paraplegia
Coexistence of Hereditary Spastic Paraplegia Type 4 and Narcolepsy: A Case Report.
Paraplegia
Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A.
Paraplegia
Four mutations of the spastin gene in Japanese families with spastic paraplegia.
Paraplegia
Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia.
Paraplegia
Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation.
Paraplegia
Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle.
Paraplegia
Novel and recurrent spastin mutations in a large series of SPG4 Italian families.
Paraplegia
Novel spastin (SPG4) mutations in Italian patients with hereditary spastic paraplegia.
Paraplegia
Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques.
Paraplegia
Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor.
Paraplegia
Spastic paraplegia due to SPAST mutations is modified by the underlying mutation and sex.
Paraplegia
Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits.
Paraplegia
Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases.
Paraplegia
Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia.
Paraplegia
The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.
Paraplegia
Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion.
Paraplegia
[Spastic paraplegia caused by a novel mutation in the spastin gene (1207C-->G, P361R)--clinical features of a patient without family history]
Paraplegia
[SPG3A-hereditary spastin paraplegia with genetic anticipation and incomplete penetrance]
Paresis
Identification of a novel mutation in the spastin gene (SPG4) in an Italian family with hereditary spastic paresis.
Peripheral Nervous System Diseases
Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques.
Prostatic Neoplasms
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Prostatic Neoplasms
Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes.
Prostatic Neoplasms
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Spastic Paraplegia, Hereditary
A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform.
Spastic Paraplegia, Hereditary
A de novo SPAST mutation leading to somatic mosaicism is associated with a later age at onset in HSP.
Spastic Paraplegia, Hereditary
A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
A novel insertion mutation in spastin gene is the cause of spastic paraplegia in a Chinese family.
Spastic Paraplegia, Hereditary
A novel mutation in the spastin gene in a family with spastic paraplegia.
Spastic Paraplegia, Hereditary
An allosteric network in spastin couples multiple activities required for microtubule severing.
Spastic Paraplegia, Hereditary
An Automated Image Analysis System to Quantify Endosomal Tubulation.
Spastic Paraplegia, Hereditary
An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.
Spastic Paraplegia, Hereditary
Autosomal dominant hereditary spastic paraplegia: report of a large Italian family with R581X spastin mutation.
Spastic Paraplegia, Hereditary
BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation.
Spastic Paraplegia, Hereditary
Clinical features of hereditary spastic paraplegia due to spastin mutation.
Spastic Paraplegia, Hereditary
Coexistence of Hereditary Spastic Paraplegia Type 4 and Narcolepsy: A Case Report.
Spastic Paraplegia, Hereditary
Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing.
Spastic Paraplegia, Hereditary
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Detection of novel mutations and review of published data suggests that hereditary spastic paraplegia caused by spastin (SPAST) mutations is found more often in males.
Spastic Paraplegia, Hereditary
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Spastic Paraplegia, Hereditary
Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria.
Spastic Paraplegia, Hereditary
Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.
Spastic Paraplegia, Hereditary
ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic.
Spastic Paraplegia, Hereditary
Exon deletions of SPG4 are a frequent cause of hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
First mutation in the nuclear localization signal sequence of spastin protein identified in a patient with hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Functional differences of short and long isoforms of spastin harboring missense mutation.
Spastic Paraplegia, Hereditary
Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Graded Control of Microtubule Severing by Tubulin Glutamylation.
Spastic Paraplegia, Hereditary
Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network.
Spastic Paraplegia, Hereditary
Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia: spastin phenotype and function.
Spastic Paraplegia, Hereditary
Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system.
Spastic Paraplegia, Hereditary
Identification of the Drosophila melanogaster homolog of the human spastin gene.
Spastic Paraplegia, Hereditary
Infantile onset of hereditary spastic paraplegia poorly predicts the genotype.
Spastic Paraplegia, Hereditary
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance.
Spastic Paraplegia, Hereditary
Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations.
Spastic Paraplegia, Hereditary
Isoform-specific increase of spastin stability by N-terminal missense variants including intragenic modifiers of SPG4 hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape.
Spastic Paraplegia, Hereditary
Large deletion involving the 5'-UTR in the spastin gene caused mild phenotype of autosomal dominant hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing.
Spastic Paraplegia, Hereditary
Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Spastic Paraplegia, Hereditary
Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knock-out mice.
Spastic Paraplegia, Hereditary
Mutation analysis of the spastin gene (SPG4) in patients in Germany with autosomal dominant hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Mutation screening of spastin, atlastin, and REEP1 in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus.
Spastic Paraplegia, Hereditary
Novel mutations in spastin gene and absence of correlation with age at onset of symptoms.
Spastic Paraplegia, Hereditary
Novel spastin (SPG4) mutations in Italian patients with hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Oligomerization of ZFYVE27 (Protrudin) is necessary to promote neurite extension.
Spastic Paraplegia, Hereditary
Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.
Spastic Paraplegia, Hereditary
Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation - A neurophysiological study using excitability techniques.
Spastic Paraplegia, Hereditary
Pleiotropic effects of spastin on neurite growth depending on expression levels.
Spastic Paraplegia, Hereditary
Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.
Spastic Paraplegia, Hereditary
Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.
Spastic Paraplegia, Hereditary
Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation.
Spastic Paraplegia, Hereditary
Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners.
Spastic Paraplegia, Hereditary
Spastin binds to lipid droplets and affects lipid metabolism.
Spastic Paraplegia, Hereditary
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion.
Spastic Paraplegia, Hereditary
Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits.
Spastic Paraplegia, Hereditary
Spastin gene mutation in Japanese with hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Spastin gene mutations in Bulgarian patients with hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Spastin mutation screening in Chinese patients with pure hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Spastin mutations impair coordination between lipid droplet dispersion and reticulum.
Spastic Paraplegia, Hereditary
Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule.
Spastic Paraplegia, Hereditary
Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation.
Spastic Paraplegia, Hereditary
Spastin related hereditary spastic paraplegia with dysplastic corpus callosum.
Spastic Paraplegia, Hereditary
Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus.
Spastic Paraplegia, Hereditary
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III.
Spastic Paraplegia, Hereditary
Spastin, atlastin and ER relocalization are involved in axon, but not dendrite, regeneration.
Spastic Paraplegia, Hereditary
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein.
Spastic Paraplegia, Hereditary
Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.
Spastic Paraplegia, Hereditary
SPG4 gene promoter regulation via Elk1 transcription factor.
Spastic Paraplegia, Hereditary
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
Spastic Paraplegia, Hereditary
Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Systematic isolation and characterization of cDNAs encoding AAA proteins from human brain.
Spastic Paraplegia, Hereditary
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
The AAA ATPase spastin links microtubule severing to membrane modelling.
Spastic Paraplegia, Hereditary
The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.
Spastic Paraplegia, Hereditary
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.
Spastic Paraplegia, Hereditary
The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.
Spastic Paraplegia, Hereditary
The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B.
Spastic Paraplegia, Hereditary
The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.
Spastic Paraplegia, Hereditary
The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
Three novel mutations of the spastin gene in Chinese patients with hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Three novel spastin (SPG4) mutations in families with autosomal dominant hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.
Spastic Paraplegia, Hereditary
Two novel mutations in the spastin gene (SPG4) found by DHPLC mutation analysis.
Spastic Paraplegia, Hereditary
Two novel mutations in the Spastin gene of Chinese patients with hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
[Clinical characteristics and spastin gene mutation analysis on an autosomal dominant kindred with hereditary spastic paraplegia]
Spastic Paraplegia, Hereditary
[Hereditary spastic paraplegia type 4 (SPG4): clinical and molecular-genetic characteristics]
Spastic Paraplegia, Hereditary
[Spastin gene mutation in Chinese patients with hereditary spastic paraplegia]
Spinal Cord Injuries
Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching.
Starvation
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Status Epilepticus
Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.
Stomach Neoplasms
Differential expression of Scinderin and Gelsolin in gastric cancer and comparison with clinical and morphological characteristics.
Stomach Neoplasms
Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.
Stomach Neoplasms
Suppression of scinderin modulates epithelial?mesenchymal transition markers in highly metastatic gastric cancer cell line SGC?7901.
Stroke
Katanin spiral and ring structures shed light on power stroke for microtubule severing.
Tauopathies
Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.
Tauopathies
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.
Thyroid Cancer, Papillary
Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.
Urinary Bladder Neoplasms
Adseverin modulates morphology and invasive function of MCF7 cells.
Urinary Bladder Neoplasms
Adseverin: A novel cisplatin-resistant marker in the human bladder cancer cell line HT1376 identified by quantitative proteomic analysis.
html completed