The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme can interconvert the (E) isomer formed in the reaction into the (Z) isomer , although this isomerization is not part of the pathway leading to bacilysin .
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme can interconvert the (E) isomer formed in the reaction into the (Z) isomer [2], although this isomerization is not part of the pathway leading to bacilysin [3].
nonenzymatic isomerization gives (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate and (3Z)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate in the ration 50:1. Isomerization by BacB gives a 3:1 mixture of the E- and Z-isomers
the enzyme generates a mixture of 3E- and 3Z-isomers. It equilibrates the more stable 3E and less stable 3Z geometric isomers to give up to 25% of the 3Z isomer, which on subsequent reduction by BacG gives the desired 4S stereochemistry of the cyclohexanol scaffold
nonenzymatic isomerization gives (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate and (3Z)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate in the ration 50:1. Isomerization by BacB gives a 3:1 mixture of the E- and Z-isomers
the enzyme generates a mixture of 3E- and 3Z-isomers. It equilibrates the more stable 3E and less stable 3Z geometric isomers to give up to 25% of the 3Z isomer, which on subsequent reduction by BacG gives the desired 4S stereochemistry of the cyclohexanol scaffold
the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin
nonenzymatic isomerization gives (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate and (3Z)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate in the ratio 50:1. Isomerization by BacB gives a 3:1 mixture of the E- and Z-isomers
the enzyme generates a mixture of 3E- and 3Z-isomers. It equilibrates the more stable 3E and less stable 3Z geometric isomers to give up to 25% of the 3Z isomer, which on subsequent reduction by BacG gives the desired 4S stereochemistry of the cyclohexanol scaffold
the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin
nonenzymatic isomerization gives (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate and (3Z)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate in the ratio 50:1. Isomerization by BacB gives a 3:1 mixture of the E- and Z-isomers
the enzyme generates a mixture of 3E- and 3Z-isomers. It equilibrates the more stable 3E and less stable 3Z geometric isomers to give up to 25% of the 3Z isomer, which on subsequent reduction by BacG gives the desired 4S stereochemistry of the cyclohexanol scaffold
the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin
the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin
disruption of bacB, the gene in the cluster responsible for synthesizing bacilysin abolishes the bactericidal activity of Bacillus amyloliquefaciens FZB42 against Microcystis aeruginosa
the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin
the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin
BacB can be crystallized in three different crystal forms by slight modification of the crystallization conditions. The concentration of 2,4-methylpentanediol substantially influences crystallization
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5.3.3.19 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase
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