show all | hide all No of entries

Information on EC 4.1.99.17 - phosphomethylpyrimidine synthase

for references in articles please use BRENDA:EC4.1.99.17
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.17 phosphomethylpyrimidine synthase
IUBMB Comments
Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis.
Specify your search results
Select one or more organisms in this record:
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
show the reaction diagram
Select items on the left to see more content.